| Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study. | |
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MedLine Citation:
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PMID: 21061003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Extract of Ginkgo biloba (EGb), a dietary supplement used for a number of conditions including dementia, has been suggested to increase cerebral bloodflow (CBF). The purpose of this study was to determine if changes in CBF could be detected by dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI)in elderly human subjects taking EGb. METHODS: DSC-MRI was performed in nine healthy men(mean age 61±10 years) before and after 4 weeks of 60 mg EGb taken twice daily. One subject underwent six consecutive scans to evaluate intrasubject reproducibility. CBF values were computed before and after EGb, and analyzed at three different levels of spatial resolution, using voxel-based statistical parametric mapping (SPM), and regions of interest in different lobes, and all regions combined. RESULTS: Normalized intrasubject CBF (nCBF) measurements had a standard deviation of 7% and 4% in gray and white matter (WM) regions, respectively. SPM using an uncorrected, voxel-level threshold of P≤0.001 showed a small CBF increase in the left parietal-occipital region.CBF in individual lobar regions did not show any significant change post-EGb, but all regions combined showed a significant increase of non-normalized CBF after EGb (15% in white and 13% in gray matter, respectively, P≤0.0001). CONCLUSION: nCBF measured by DSC-MRI has good intrasubject reproducibility. In this small cohort of normal elderly individuals, a mild increase in CBF is found in the left parietal-occipital WM after EGb, as well as a small but statistically significant increase in global CBF. |
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Authors:
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Ameneh Mashayekh; Dzung L Pham; David M Yousem; Mercedes Dizon; Peter B Barker; Doris D M Lin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Neuroradiology Volume: 53 ISSN: 1432-1920 ISO Abbreviation: Neuroradiology Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-28 Completed Date: 2011-06-23 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
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Languages: eng Pagination: 185-91 Citation Subset: IM |
Affiliation:
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Division of Neuroradiology, Department of Radiology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street/Phipps B100-D, Baltimore, MD 21287, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity
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drug effects,
physiology Cerebrovascular Circulation / drug effects*, physiology* Ginkgo biloba / chemistry* Humans Magnetic Resonance Angiography / methods* Male Middle Aged Pilot Projects Plant Extracts / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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P41 RR015241-10/RR/NCRR NIH HHS; P41RR015241/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts |
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