Document Detail


Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: results from a pilot, randomized, and controlled trial.
MedLine Citation:
PMID:  23303903     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To estimate the effects of ginger on apoptosis, proliferation, and differentiation in the normal-appearing colonic mucosa, we randomized 20 people at increased risk for colorectal cancer to 2.0 g of ginger or placebo daily for 28 days in a pilot trial. Overall expression and distributions of Bax, Bcl-2, p21, hTERT, and MIB-1 (Ki-67) in colorectal crypts in rectal mucosa biopsies were measured using automated immunohistochemistry and quantitative image analysis. Relative to placebo, Bax expression in the ginger group decreased 15.6% (P = 0.78) in the whole crypts, 6.6% (P = 0.95) in the upper 40% (differentiation zone) of crypts, and 21.7% (P = 0.67) in the lower 60% (proliferative zone) of crypts; however, there was a 19% increase (P = 0.14) in Bax expression in the upper 40% relative to the whole crypt. While p21 and Bcl-2 expression remained relatively unchanged, hTERT expression in the whole crypts decreased by 41.2% (P = 0.05); the estimated treatment effect on hTERT expression was larger in the upper 40% of crypts (-47.9%; P = 0.04). In the ginger group, MIB-1 expression decreased in the whole crypts, upper 40% of crypts, and lower 60% of crypts by 16.9% (P = 0.39), 46.8% (P = 0.39), and 15.3% (P = 0.41), respectively. These pilot study results suggest that ginger may reduce proliferation in the normal-appearing colorectal epithelium and increase apoptosis and differentiation relative to proliferation--especially in the differentiation zone of the crypts and support a larger study to further investigate these results.
Authors:
Jessica Citronberg; Roberd Bostick; Thomas Ahearn; D Kim Turgeon; Mack T Ruffin; Zora Djuric; Ananda Sen; Dean E Brenner; Suzanna M Zick
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-09
Journal Detail:
Title:  Cancer prevention research (Philadelphia, Pa.)     Volume:  6     ISSN:  1940-6215     ISO Abbreviation:  Cancer Prev Res (Phila)     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-10-21     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101479409     Medline TA:  Cancer Prev Res (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apoptosis
Biological Markers / analysis,  metabolism
Cell Cycle
Colorectal Neoplasms / prevention & control*
Dietary Supplements*
Disease Susceptibility / therapy
Female
Ginger*
Humans
Intestinal Mucosa / drug effects,  metabolism*
Male
Middle Aged
Pilot Projects
Plant Extracts / therapeutic use*
Powders
Risk Factors
Grant Support
ID/Acronym/Agency:
CA130810/CA/NCI NIH HHS; K07 CA102592/CA/NCI NIH HHS; K07CA102592/CA/NCI NIH HHS; K24CA80846/CA/NCI NIH HHS; P30 CA 48592/CA/NCI NIH HHS; P30 CA047904/CA/NCI NIH HHS; UL1 RR024986/RR/NCRR NIH HHS; UL1RR024986/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Plant Extracts; 0/Powders
Comments/Corrections
Comment In:
Cancer Prev Res (Phila). 2013 Apr;6(4):257-62   [PMID:  23559451 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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