Document Detail

The effects of gestational age and birth weight on false-positive newborn-screening rates.
MedLine Citation:
PMID:  20974783     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Newborn-screening false-positive rates (FPRs) are disproportionately increased in preterm infants. The objective of this study was to determine variation in newborn screening FPRs according to birth weight and gestational age. Our secondary objective was to examine the effect of postnatal age on FPRs in preterm infants.
METHODS: The Ohio State Newborn Screening Program Database was analyzed to determine the overall and birth weight-specific FPRs for 18 analytes. Data were stratified into birth weight categories (<1000 g, 1000-1499 g, 1500-2499 g, 2500-3999 g, and >4000 g). In addition, to examine the effect of postnatal age on FPRs, we examined the 2 analytes with the highest FPRs, thyrotropin with back-up thyroxine and 17-hydroxyprogesterone, in infants whose gestational age was <32 weeks, determined on the basis of postnatal age at screening.
RESULTS: Data from 448 766 neonates were reviewed. Infants with very low birth weight (VLBW) comprised 1.9% of the study cohort, but accounted for 18% of false-positive results. For 14 of 18 analytes studied, FPRs increased with decreasing birth weight/gestational age and were significantly increased in infants with VLBW compared with infants who weighed 2500 to 3999 g (P < .001). Thyrotropin/back-up thyroxine and 17-hydroxyprogesterone accounted for 62% of total false-positive results in VLBW infants. When blood specimens were collected at a postnatal age of ≥ 48 hours in infants born at <32 weeks, a 44% relative reduction in 17-hydroxyprogesterone false-positive results was detected.
CONCLUSIONS: False-positive newborn-screening rates are disproportionately increased in VLBW infants. FPRs may be reduced by delaying screening of <32 weeks' gestation, preterm infants until 24 to 48 hours' postnatal age.
Jonathan L Slaughter; Jareen Meinzen-Derr; Susan R Rose; Nancy D Leslie; Ram Chandrasekar; Sharon M Linard; Henry T Akinbi
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Publication Detail:
Type:  Journal Article     Date:  2010-10-25
Journal Detail:
Title:  Pediatrics     Volume:  126     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  910-6     Citation Subset:  AIM; IM    
Cincinnati Children's Hospital Medical Center, Division of Neonatology, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA.
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MeSH Terms
17-alpha-Hydroxyprogesterone / blood*
Birth Weight*
False Positive Reactions
Gestational Age*
Infant, Extremely Low Birth Weight / blood*
Infant, Low Birth Weight / blood*
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight / blood*
Neonatal Screening*
Reference Values
Thyrotropin / blood*
Thyroxine / blood*
Reg. No./Substance:
68-96-2/17-alpha-Hydroxyprogesterone; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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