Document Detail

Effects of Gene-environmental Interaction on Noise-induced Hearing Threshold Levels for High Frequencies (HTLHF).
MedLine Citation:
PMID:  21786748     Owner:  NLM     Status:  Publisher    
In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job-exposure matrix. Approximately 64.6% of the participants' exposure in Leq-8h was above 90 dBA. The mean HTLHF was 32.1 dB. A significant dose-response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (Leq-40y). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null and GSTP1 Ile105/Ile105 genotypes were susceptible to the HTLHF when their Leq-40y were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers were exposed to high noise levels.
Cheng-Yu Lin; Tung-Sheng Shih; Yueliang Leon Guo; Jiunn-Liang Wu; Yih-Min Sun; Perng-Jy Tsai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-25
Journal Detail:
Title:  Environmental science & technology     Volume:  -     ISSN:  1520-5851     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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