| Effects of Gene-environmental Interaction on Noise-induced Hearing Threshold Levels for High Frequencies (HTLHF). | |
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MedLine Citation:
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PMID: 21786748 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job-exposure matrix. Approximately 64.6% of the participants' exposure in Leq-8h was above 90 dBA. The mean HTLHF was 32.1 dB. A significant dose-response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (Leq-40y). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null and GSTP1 Ile105/Ile105 genotypes were susceptible to the HTLHF when their Leq-40y were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers were exposed to high noise levels. |
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Authors:
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Cheng-Yu Lin; Tung-Sheng Shih; Yueliang Leon Guo; Jiunn-Liang Wu; Yih-Min Sun; Perng-Jy Tsai |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-25 |
Journal Detail:
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Title: Environmental science & technology Volume: - ISSN: 1520-5851 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0213155 Medline TA: Environ Sci Technol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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