Document Detail

Effects of gamma-aminobutyric acid on the Hering-Breuer inspiration-inhibiting reflex.
MedLine Citation:
PMID:  20033306     Owner:  NLM     Status:  MEDLINE    
Acute experiments on rats were performed to study the effects of intraventricular microinjections of gamma-aminobutyric acid (GABA) on the volume-time parameters of external respiration and the inspiration-inhibiting Hering-Breuer reflex. The state of this reflex before and after GABA administration was assessed in terms of the extent of changes in the duration and amplitude of inspiratory oscillations in intrathoracic pressure in response to end-expiratory occlusion of the trachea. Administration of 20 microM GABA into the lateral ventricles of the brain decreased the minute ventilation (due to reductions in the respiratory frequency and respiratory volume), weakened respiratory muscle contractions, and decreased the peak airflow rate on inspiration and expiration. The response to end-expiratory occlusion decreased significantly after administration of GABA, demonstrating the involvement of GABAergic mechanisms in mediating the inspiration-inhibiting Hering-Breuer reflex.
N P Aleksandrova; V G Aleksandrov; T G Ivanova
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Publication Detail:
Type:  Journal Article     Date:  2009-12-22
Journal Detail:
Title:  Neuroscience and behavioral physiology     Volume:  40     ISSN:  1573-899X     ISO Abbreviation:  Neurosci. Behav. Physiol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330471     Medline TA:  Neurosci Behav Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia.
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MeSH Terms
Air Pressure
Brain / physiology*
Inhalation / physiology*
Injections, Intraventricular
Lateral Ventricles
Peak Expiratory Flow Rate / physiology
Rats, Wistar
Reflex / physiology*
Respiratory Muscles / physiology
Thorax / physiology
Time Factors
Trachea / physiology
gamma-Aminobutyric Acid / cerebrospinal fluid,  metabolism*
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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