| Effects of GM-CSF on the neural progenitor cells. | |
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MedLine Citation:
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PMID: 15371725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent hematopoietic cytokine, which stimulates stem cell proliferation in the bone marrow. We now report that GM-CSF receptors expressed on neural progenitor cells and can mediate a biological response in cells to treat with GM-CSF treated neural progenitor cells exhibited a proliferative response and a marked decrease in terminal differentiation to mature neuron or astrocytes. GM-CSF treatment also suppressed neural progenitor cell apoptosis. These findings suggest that GM-CSF can stimulate the proliferation and inhibit the apoptosis of neural progenitor cells to expand the progenitor population, and that GM-CSF has a potential role in neural development or repair. |
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Authors:
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Jin Kyun Kim; Byung Hyun Choi; Hyung Chun Park; So Ra Park; Young Soo Kim; Seung Hwan Yoon; Hyun Seon Park; Eun Young Kim; Yoon Ha |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 15 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-16 Completed Date: 2005-01-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 2161-5 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Inha University College of Medicine, 7-206, shinheung-dong 3ga, Chung-gu, Inchon, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects, physiology Dose-Response Relationship, Drug Granulocyte-Macrophage Colony-Stimulating Factor / metabolism, pharmacology* Humans Male Mice Mice, Inbred ICR Neurons / cytology, drug effects*, metabolism Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / agonists, biosynthesis Stem Cells / cytology, drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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