Document Detail


Effects of GM-CSF on the neural progenitor cells.
MedLine Citation:
PMID:  15371725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent hematopoietic cytokine, which stimulates stem cell proliferation in the bone marrow. We now report that GM-CSF receptors expressed on neural progenitor cells and can mediate a biological response in cells to treat with GM-CSF treated neural progenitor cells exhibited a proliferative response and a marked decrease in terminal differentiation to mature neuron or astrocytes. GM-CSF treatment also suppressed neural progenitor cell apoptosis. These findings suggest that GM-CSF can stimulate the proliferation and inhibit the apoptosis of neural progenitor cells to expand the progenitor population, and that GM-CSF has a potential role in neural development or repair.
Authors:
Jin Kyun Kim; Byung Hyun Choi; Hyung Chun Park; So Ra Park; Young Soo Kim; Seung Hwan Yoon; Hyun Seon Park; Eun Young Kim; Yoon Ha
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  15     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-16     Completed Date:  2005-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  2161-5     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Inha University College of Medicine, 7-206, shinheung-dong 3ga, Chung-gu, Inchon, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects,  physiology
Dose-Response Relationship, Drug
Granulocyte-Macrophage Colony-Stimulating Factor / metabolism,  pharmacology*
Humans
Male
Mice
Mice, Inbred ICR
Neurons / cytology,  drug effects*,  metabolism
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / agonists,  biosynthesis
Stem Cells / cytology,  drug effects*,  metabolism
Chemical
Reg. No./Substance:
0/Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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