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Effects of the GABA(B) receptor agonist baclofen administered orally on normal food intake and intraperitoneally on fat intake in non-deprived rats.
MedLine Citation:
PMID:  23123347     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It has been previously reported that the GABA(B) receptor agonist baclofen decreases food intake after oral administration and fat intake after intraperitoneal administration. The aim of the study was to investigate the effects of baclofen (1-4mg/ kg) administered orally (Experiment 1) on food intake in non-deprived rats (n=6) and intraperitoneally (Experiment 2) on fat intake in non-deprived rats (n=8) that were naïve to baclofen (1(st) set of trials) and in the same group of rats after they were sub-chronically exposed to baclofen (2(nd) set of trials). The results from Experiment 1 show that baclofen had no effects on food intake during the 1(st) set of trials, but the 2 and 4mg/ kg doses significantly increased food consumption during the 2(nd) set of trials. Baclofen produced sedation during the 1(st) set of trials, but tolerance occurred to this effect and was not apparent during the 2(nd) set of trials. These observations suggest that the motor effects may have competed with the hyperphagic effects of baclofen during the 1(st) set of trials. The data from Experiment 2 show that baclofen had no effects on fat intake during either the 1(st) or 2(nd) set of trials. The results of the study thus indicate that orally administrated baclofen increases food intake and intraperitoneal administration has no effect on fat intake in non-deprived rats under the conditions used in this study. These findings may have important implications for research on the use of baclofen in studies concerned with ingestive behaviours.
Authors:
Rasneer S Bains; Ivor S Ebenezer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-1
Journal Detail:
Title:  European journal of pharmacology     Volume:  -     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO 1 2DT, England, and.
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