Document Detail

Effects of forced running exercise on cognitive function and its relation to zinc homeostasis-related gene expression in rat hippocampus.
MedLine Citation:
PMID:  20703826     Owner:  NLM     Status:  In-Data-Review    
Voluntary exercise has been implicated to be beneficial for overall health and cognitive function in both clinical and experimental studies, but little is presently known about forced physical exercise on cognition and underlying molecular mechanism. We have used real-time RT-PCR to analyze gene expression in hippocampus, in the presence and absence of physical exercise, during spatial learning of rats in the Morris water maze. Our results show distinct zinc homeostasis-related gene expression profiles associated with learning and memory. Rats with physical exercise (EXP) showed a significant up-regulation of mRNA expression of zinc transporter-2 (ZnT-2), ZnT-4, ZnT-5, ZnT-6, and ZnT-7, metallothionein-1 (MT-1)-MT-3, divalent cation transporter-1, and Zrt-Irt-like proteins-7 in hippocampus when compared with control rats. In addition, spatial learning ability was improved in EXP rats compared with that in control group. This study provides the first comparative view of zinc homeostasis-related gene expression in hippocampus following forced physical exercise. These results suggested that forced physical exercise may provide a simple means to maintain brain function and promote learning capacity. Results of this study also suggest that exercise mobilizes zinc homeostasis-related gene expression profiles that would be predicted to benefit brain plasticity processes.
Hong Ni; Chao Li; Xing Feng; Jian-Nong Cen
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Publication Detail:
Type:  Journal Article     Date:  2010-08-12
Journal Detail:
Title:  Biological trace element research     Volume:  142     ISSN:  1559-0720     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  704-12     Citation Subset:  IM    
Neurology Laboratory, The Children's Hospital Affiliated to Soochow University, No.303, Jingde Road, 215003, Suzhou, People's Republic of China,
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