Document Detail

Effects of a Flavonoid-rich Juice on Inflammation, Oxidative Stress, and Immunity in Elite Swimmers: A Metabolomics Based Approach.
MedLine Citation:
PMID:  23070789     Owner:  NLM     Status:  Publisher    
The effects of a flavonoid-rich fresh fruit/vegetable juice (JUICE) on chronic resting and post-exercise inflammation, oxidative stress, immune function, and metabolic profiles (metabolomics analysis, GC-MS platform) in elite sprint and middle-distance swimmers were studied. Utilizing a randomized, crossover design with a 3-wk washout period, swimmers (n = 9) completed 10-d training with or without 16 fl oz JUICE (230 mg flavonoids) ingested pre- and post-workout. Blood samples were taken pre-supplementation, post-10-d supplementation, and immediately post-exercise, with data analyzed using a 2 x 3 repeated measures ANOVA. Pre-study blood samples were also acquired from non-athletic controls (n = 7, age and weight matched) and revealed higher levels of oxidative stress in the swimmers, no differences in inflammation or immune function, and a distinct separation in global metabolic scores [R2Y(cum) = .971]. Swim workouts consisted of high-intensity intervals (1:1, 1:2 swim-to-rest ratio), and induced little inflammation, oxidative stress, or immune changes. A distinct separation in global metabolic scores was found pre-to-post-exercise [R2Y(cum) = 0.976], with shifts detected in a small number of metabolites related to substrate utilization. No effect of 10-d JUICE was found on chronic resting levels or post-exercise inflammation, oxidative stress, immune function, and shifts in metabolites. In conclusion, sprint and middle-distance swimmers had a slight chronic elevation in oxidative stress compared to nonathletic controls, experienced a low magnitude of post-workout perturbations in the biomarkers included in this study, and received no apparent benefit other than added nutrient intake from ingesting JUICE pre- and post-workout for 10 days.
Amy M Knab; David C Nieman; Nicholas D Gillitt; R Andrew Shanely; Lynn Cialdella-Kam; Dru A Henson; Wei Sha
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  -     ISSN:  1543-2742     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC.
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