Document Detail


Effects of fetal exposure to 4-n-octylphenol on mammary tumorigenesis in rats.
MedLine Citation:
PMID:  20668312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to investigate the effect of fetal exposure to 4-n-octylphenol (OP) on the induction of mammary tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) in rats. MATERIALS AND METHODS: All rats which showed vaginal plugs or sperm by vaginal smear test after mating were fed a normal diet only, or a diet mixed with 10, 100, 1000 ppm OP throughout the pregnancy period and from day 13 of pregnancy to the end of the pregnancy. No abnormal pregnancy was seen in any of the rats. Pups were given 10 mg DMBA by gastric intubation 50 days after birth. RESULTS: Uterine weight decrease was observed in pups with fetal exposure to 1000 ppm OP throughout the pregnancy period. No endocrine disrupting conditions, such as persistent estrus, anovulatory ovaries or abnormal lactation in the mammary glands were seen in pups with fetal exposure to OP. However, fetal exposure to 100 and 1000 ppm OP throughout pregnancy period enhanced the early incidence and number of mammary carcinomas (MCs) while it did not enhance the incidence and number of benign proliferative lesions (PLs) which consisted of solid masses (fibroadenoma and lobular hyperplasia) and gross cysts. CONCLUSION: These results suggest that fetal exposure to the very weak estrogenicity of OP could enhance the induction of MCs but not affect the induction of PLs.
Authors:
Hiroaki Kawaguchi; Noriaki Miyoshi; Yoko Miyamoto; Masakazu Souda; Yoshihisa Umekita; Nobuhiro Yasuda; Hiroki Yoshida
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  24     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  463-70     Citation Subset:  IM    
Affiliation:
DVM, Department of Veterinary Pathology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene / toxicity
Animals
Body Weight / drug effects
Breast Neoplasms / epidemiology
Carcinogens / toxicity
Cell Division / drug effects
Diethylstilbestrol / toxicity
Dose-Response Relationship, Drug
Estradiol / toxicity
Estrus / drug effects
Female
Fetus / drug effects
Humans
Mammary Neoplasms, Animal / chemically induced*,  pathology
Organ Size / drug effects
Phenols / toxicity*
Pregnancy
Rats
Rats, Sprague-Dawley
Testosterone Propionate / toxicity
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Phenols; 1806-26-4/4-octylphenol; 50-28-2/Estradiol; 56-53-1/Diethylstilbestrol; 57-85-2/Testosterone Propionate; 57-97-6/9,10-Dimethyl-1,2-benzanthracene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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