| Effects of fenoldopam mesylate on central hemodynamics and renal flow in patients undergoing cardiac surgery: color Doppler echocardiographic evaluation. | |
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MedLine Citation:
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PMID: 19553140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate the effect of 0.1 microg/kg/min of fenoldopam mesylate on renal flow and central hemodynamics measured by echocardiography in hemodynamically stable patients with preserved renal function undergoing cardiac surgery. DESIGN: Experimental observational study. SETTING: Single-institutional community hospital study. PARTICIPANTS: Thirty patients undergoing cardiac surgery. INTERVENTION: Fenoldopam mesylate infusion (0.1 microg/kg/min) in patients undergoing cardiopulmonary bypass. MEASUREMENTS AND MAIN RESULTS: Doppler measurements of renal blood flow and echocardiographic hemodynamic determinations after Doppler echocardiography measured flux velocities of the main, segmental, and interlobar and interlobular right renal arteries. The authors calculated the resistive index of all the renal segments studied. Moreover, the authors measured the flux of the main renal artery and its diameter as well as the main hemodynamic variables. All the measurements were performed in the intensive care unit setting at baseline and 20 minutes after the infusion of 0.1 microg/kg/min of fenoldopam mesylate. Fenoldopam mesylate infusion significantly increased blood flow in all renal compartments, thus improving the resistive index. The study showed that fenoldopam mesylate infusion does not induce any significant change of the heart rate or arterial pressure, cardiac output, preload, or wall stress. CONCLUSIONS: In hemodynamically stable cardiac surgery patients with preserved renal function, an infusion of 0.1 microg/kg/min of fenoldopam mesylate has no influence on systemic hemodynamics while increasing renal blood flow. |
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Authors:
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Massimo Meco; Silvia Cirri |
Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2009-06-24 |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 24 ISSN: 1532-8422 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 58-62 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Cardiac Surgery and Anesthesia and Intensive Care Department, Instituto Clinico Sant'Ambrogio, Via Faravelli 16, 20171 Milan, Italy. massimo.meco@virgilio.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Flow Velocity / drug effects Blood Pressure / drug effects Cardiac Surgical Procedures* Cardiopulmonary Bypass Dopamine Agonists / administration & dosage*, pharmacology Echocardiography, Doppler, Color* Female Fenoldopam / administration & dosage*, pharmacology Hemodynamics / drug effects Humans Kidney / blood supply* Male Renal Artery / physiology, ultrasonography Renal Circulation / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agonists; 67227-56-9/Fenoldopam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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