| Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits. | |
| | |
MedLine Citation:
|
PMID: 20720232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To investigate the effects of fasudil, a Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor, on normal or impaired optic nerve head (ONH) blood flow in a rabbit model. METHODS: ONH blood flow was measured by laser speckle flowgraphy. Changes in ONH blood flow were examined during a continuous intravenous infusion of fasudil with and without the application of N(G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor. Effects of topical fasudil on ONH blood flow were investigated in normal eyes or models of ocular circulation impairment induced by the application of endothelin (ET)-1. Visual-evoked potentials (VEPs) and morphologic and histologic changes were also analyzed in the ET-1-injected eyes. RESULTS: A continuous intravenous infusion of fasudil had no significant effect on normal ONH blood flow, yet it prevented or improved the ONH blood flow impairment induced by the intravenous injection of L-NAME. Repeated intravitreal injections of ET-1 twice a week for 4 weeks decreased the ONH blood flow, prolonged the VEPs' implicit time, enlarged the optic cup, and decreased retinal ganglion cells. Multiple doses of topical fasudil ameliorated the ONH impairments caused by ET-1. CONCLUSIONS: These results show that systemic or topical fasudil suppresses impairment of ONH blood flow, function, and morphology induced by L-NAME or ET-1. A ROCK inhibitor can be useful for the treatment of impaired ONH blood flow. |
| | |
Authors:
|
Tetsuya Sugiyama; Maho Shibata; Sumiko Kajiura; Takashi Okuno; Masahiro Tonari; Hidehiro Oku; Tsunehiko Ikeda |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-05 |
Journal Detail:
|
Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-06 Completed Date: 2011-02-07 Revised Date: 2011-03-04 |
Medline Journal Info:
|
Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 64-9 Citation Subset: IM |
Affiliation:
|
Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan. tsugiyama@poh.osaka-med.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
/
administration & dosage,
analogs & derivatives* Administration, Topical Animals Blood Flow Velocity / drug effects Blood Pressure / drug effects Endothelin-1 / pharmacology Evoked Potentials, Visual / drug effects Infusions, Intravenous Intraocular Pressure / drug effects Laser-Doppler Flowmetry Male NG-Nitroarginine Methyl Ester / pharmacology Optic Disk / blood supply* Protein Kinase Inhibitors / administration & dosage* Rabbits Regional Blood Flow / drug effects rho-Associated Kinases / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
|
0/Endothelin-1; 0/Protein Kinase Inhibitors; 103745-39-7/fasudil; 50903-99-6/NG-Nitroarginine Methyl Ester; 84477-87-2/1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; EC 2.7.11.1/rho-Associated Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The elastin fiber system between and adjacent to collector channels in the human juxtacanalicular ti...
Next Document: Drug interactions and toxicities associated with the antiviral management of cytomegalovirus infecti...