Document Detail


Effects of experimental sleep restriction on caloric intake and activity energy expenditure.
MedLine Citation:
PMID:  23392199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Epidemiologic studies link short sleep duration to obesity and weight gain. Insufficient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin.
METHODS: We conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin.
RESULTS: Caloric intake in the sleep-restricted group increased by +559 kcal/d (SD, 706 kcal/d, P=.006) and decreased in the control group by -118 kcal/d (SD, 386 kcal/d, P=.51) for a net change of +677 kcal/d (95% CI, 148-1,206 kcal/d; P=.014). Sleep restriction was not associated with changes in activity energy expenditure (P=.62). No change was seen in levels of leptin (P=.27) or ghrelin (P=.21).
CONCLUSIONS: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction.
TRIAL REGISTRATION: ClinicalTrials.gov; No.: NCT01334788; URL: www.clinicaltrials.gov.
Authors:
Andrew D Calvin; Rickey E Carter; Taro Adachi; Paula G Macedo; Felipe N Albuquerque; Christelle van der Walt; Jan Bukartyk; Diane E Davison; James A Levine; Virend K Somers
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  144     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2013-09-30     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-86     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01334788
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Energy Intake / physiology*
Energy Metabolism / physiology*
Female
Ghrelin / blood
Humans
Leptin / blood
Male
Motor Activity / physiology*
Patient Compliance
Sleep Deprivation / physiopathology*
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
096071//PHS HHS; 1ULI RR024150/RR/NCRR NIH HHS; HL114024/HL/NHLBI NIH HHS; HL114676/HL/NHLBI NIH HHS; HL65176/HL/NHLBI NIH HHS; HL96071/HL/NHLBI NIH HHS; R01 HL114024/HL/NHLBI NIH HHS; R01 HL114024/HL/NHLBI NIH HHS; R201 HL096071/HL/NHLBI NIH HHS; R21 HL096071/HL/NHLBI NIH HHS; UL1 RR024150/RR/NCRR NIH HHS; UL1 RR024150/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Leptin
Comments/Corrections
Comment In:
Chest. 2013 Aug;144(2):711   [PMID:  23918122 ]
Chest. 2013 Aug;144(2):711-2   [PMID:  23918123 ]

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