Document Detail


Effects of Exercise Training on Nitric Oxide Synthase in the Kidney of Spontaneously Hypertensive Rats.
MedLine Citation:
PMID:  23216343     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Exercise training is known to produce antihypertensive effects in humans and animals with hypertension, and has renal protective effects in animal models of hypertension and chronic renal failure. However, the mechanisms regulating these effects of exercise training remain unclear The present study examined the effects of exercise training on nitric oxide synthase (NOS) in the kidneys of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats Male SHR and WKY rats were randomly divided into a sedentary group and a treadmill exercise group for 8 weeks. Systolic blood pressure (SBP) was measured every 2 weeks by the tail-cuff method, and urine and blood samples were collected after the exercise protocol. NOS activity and protein expression and eNOS phosphorylation in the kidney were examined. Exercise training significantly lowered the SBP, decreased urinary albumin excretion, TBARS level, and renal NADPH oxidase activity, and increased creatinine clearance in SHR. Exercise training significantly increased plasma and urine nitrate/nitrite, NOS activity, and endothelial and neuronal NOS (eNOS and nNOS) expression, and decreased eNOS phosphorylation at Ser-1177 and Thr-495 in the kidney of SHR and WKY rats. Renal NOS may be involved in the antihypertensive and renal protective effects of exercise training in SHR. © 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Wiley Publishing Asia Pty Ltd.
Authors:
Daisuke Ito; Osamu Ito; Peng-Yu Cao; Nobuyoshi Mori; Chihiro Suda; Yoshikazu Muroya; Kenta Takashima; Sadayoshi Ito; Masahiro Kohzuki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-6
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
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