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Effects of Exercise Therapy on Cardiorespiratory Fitness in Schizophrenia Patients.
MedLine Citation:
PMID:  22525773     Owner:  NLM     Status:  Publisher    
BACKGROUND: Increased mortality in schizophrenia is caused largely by coronary heart disease. Low cardiorespiratory fitness (CRF) is a key factor for coronary heart disease mortality. We compared CRF in patients with schizophrenia to CRF of matched, healthy controls and reference values. Also, we examined the effects of exercise therapy on CRF in schizophrenia patients and controls. METHODS: Sixty-three schizophrenia patients and 55 controls, matched for gender, age, and socioeconomic status, were randomized to exercise (n=31) or occupational therapy (n=32) and controls to exercise (n=27) or life-as-usual (n=28). CRF was assessed with an incremental cardiopulmonary exercise test and defined as the highest relative oxygen uptake (VO2peak) and peak work rate (Wpeak). Minimal compliance was 50% of sessions (n=52). RESULTS: Male and female schizophrenia patients had a relative VO2peak of 34.3 (±9.9) ml·kg·min and 24.0 (±4.5) ml·kg·min, respectively. Patients had higher resting heart rate (p<.01) and lower peak heart rate (p<.001), peak systolic blood pressure (p=.02), relative VO2peak (p<.01), Wpeak (p<.001), respiratory exchange rate (p<.001), minute ventilation (p=.02), and heart rate recovery (p<.001) than controls. Relative VO2peak was 90.5 ± 19.7% (p<.01) of predicted relative VO2peak in male and 95.9 ± 14.9% (p=.18) in female patients. In patients, exercise therapy increased relative VO2peak compared to decreased relative VO2peak after occupational therapy. In controls, relative VO2peak increased after exercise therapy and to a lesser extend after life-as-usual (group: p<.01; randomization: p=.03). Exercise therapy increased Wpeak in patients and controls compared to decreased Wpeak in nonexercising patients and controls (p<.001). CONCLUSION: Patients had lower CRF-levels compared to controls and reference values. Exercise therapy increased VO2peak and Wpeak in patients and controls. VO2peak and Wpeak decreased in non-exercising patients.
Thomas W Scheewe; Tim Takken; René S Kahn; Wiepke Cahn; Frank J G Backx
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-19
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands 2 Child Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands 3 Rudolf Magnus Institute for Neuroscience, Department of Rehabilitation, Nursing science & Sports, University Medical Center Utrecht, Utrecht, the Netherlands.
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