Document Detail


Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study.
MedLine Citation:
PMID:  22418276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants.
OBJECTIVE: To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise.
METHODS: We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or pedaling a cycle ergometer for 30 minutes every hour over 4 hours in a climate-controlled chamber with a target ventilation of 20 L/min/m2 body surface area.
RESULTS: Intermittent moderate-intensity exercise induced a systemic proinflammatory response characterized by increases in leukocyte counts, C-reactive protein, monocyte chemoattractant protein-1, and interleukin-6, but did not change coagulation tendency or heart rate variability.
CONCLUSION: Interpretation of pollutant-induced inflammatory responses in inhalational exposure studies should account for signals and noises caused by exercise, especially when the effect size is small.
Authors:
Aneesh Donde; Hofer Wong; Jessica Frelinger; Karron Power; John R Balmes; Mehrdad Arjomandi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  54     ISSN:  1536-5948     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-10     Completed Date:  2012-08-09     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollutants / metabolism*
Autonomic Nervous System / physiopathology*
Bicycling / physiology*
Blood Coagulation / physiology*
C-Reactive Protein / analysis
Chemokine CCL2 / blood
Female
Heart Rate / physiology
Humans
Inflammation / physiopathology*
Inhalation Exposure
Interleukin-6 / blood
Leukocyte Count
Male
Running / physiology*
Grant Support
ID/Acronym/Agency:
K23 HL083099/HL/NHLBI NIH HHS; K23 HL083099/HL/NHLBI NIH HHS; K23 HL083099-01A1/HL/NHLBI NIH HHS; K23 HL083099-02/HL/NHLBI NIH HHS; K23 HL083099-03/HL/NHLBI NIH HHS; K23 HL083099-04/HL/NHLBI NIH HHS; K23 HL083099-05/HL/NHLBI NIH HHS; L30 HL082326/HL/NHLBI NIH HHS; L30 HL082326-01/HL/NHLBI NIH HHS; L30 HL082326-02/HL/NHLBI NIH HHS; L30 HL082326-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/CCL2 protein, human; 0/Chemokine CCL2; 0/IL6 protein, human; 0/Interleukin-6; 9007-41-4/C-Reactive Protein
Comments/Corrections

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