| Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study. | |
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MedLine Citation:
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PMID: 22418276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants. OBJECTIVE: To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise. METHODS: We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or pedaling a cycle ergometer for 30 minutes every hour over 4 hours in a climate-controlled chamber with a target ventilation of 20 L/min/m2 body surface area. RESULTS: Intermittent moderate-intensity exercise induced a systemic proinflammatory response characterized by increases in leukocyte counts, C-reactive protein, monocyte chemoattractant protein-1, and interleukin-6, but did not change coagulation tendency or heart rate variability. CONCLUSION: Interpretation of pollutant-induced inflammatory responses in inhalational exposure studies should account for signals and noises caused by exercise, especially when the effect size is small. |
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Authors:
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Aneesh Donde; Hofer Wong; Jessica Frelinger; Karron Power; John R Balmes; Mehrdad Arjomandi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine Volume: 54 ISSN: 1536-5948 ISO Abbreviation: J. Occup. Environ. Med. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-10 Completed Date: 2012-08-09 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9504688 Medline TA: J Occup Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 466-70 Citation Subset: IM |
Affiliation:
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Human Exposure Laboratory, Division of Occupational and Environmental Medicine, University of California San Francisco, San Francisco, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pollutants / metabolism* Autonomic Nervous System / physiopathology* Bicycling / physiology* Blood Coagulation / physiology* C-Reactive Protein / analysis Chemokine CCL2 / blood Female Heart Rate / physiology Humans Inflammation / physiopathology* Inhalation Exposure Interleukin-6 / blood Leukocyte Count Male Running / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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K23 HL083099/HL/NHLBI NIH HHS; K23 HL083099/HL/NHLBI NIH HHS; K23 HL083099-01A1/HL/NHLBI NIH HHS; K23 HL083099-02/HL/NHLBI NIH HHS; K23 HL083099-03/HL/NHLBI NIH HHS; K23 HL083099-04/HL/NHLBI NIH HHS; K23 HL083099-05/HL/NHLBI NIH HHS; L30 HL082326/HL/NHLBI NIH HHS; L30 HL082326-01/HL/NHLBI NIH HHS; L30 HL082326-02/HL/NHLBI NIH HHS; L30 HL082326-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/CCL2 protein, human; 0/Chemokine CCL2; 0/IL6 protein, human; 0/Interleukin-6; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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