Document Detail

The effects of exercise intensity on p-NR2B expression in cerebral ischemic rats.
MedLine Citation:
PMID:  22931702     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The current study explored the effects of treadmill exercise intensity on functional recovery and hippocampal phospho-NR2B (p-NR2B) expression in cerebral ischemic rats, induced by permanent middle cerebral artery occlusion (MCAO) surgery.
METHOD: Adult male Sprague-Dawley rats were randomly divided into four groups, including sham, no exercise (NE), low intensity training (LIT, v = 15 m/min), and moderate intensity training groups (MIT, v = 20 m/min). At different time points, the hippocampal expressions of p-NR2B and total NR2B were examined. In addition, neurological deficit score (NDS), body weight, and 2,3,5-triphenyltetrazolium chloride (TTC) staining were used to evaluate brain infarct volume as assessments of post-stroke functional recovery. In order to investigate the effect of exercise on survival, the mortality rate was also recorded.
RESULTS: The results showed that treadmill exercise significantly decreased hippocampal expression of p-NR2B but didn't change the total NR2B, compared to the NE group on the 3rd, 7th, and 14th days following MCAO surgery. The effect on changes in p-NR2B levels, body weight, and brain infarct volume were more significant in the LIT compared to the MIT group.
DISCUSSION AND CONCLUSION: The current findings demonstrate that physical exercise can produce neuroprotective effects, in part by down-regulating p-NR2B expression. Furthermore, the appropriate intensity of physical exercise is critical for post-stroke rehabilitation.
Anjing Zhang; Yulong Bai; Yongshan Hu; Feng Zhang; Yi Wu; Yang Wang; Ping Zheng; Qiang He
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  39     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-30     Completed Date:  2012-11-01     Revised Date:  2013-02-13    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  613-8     Citation Subset:  IM    
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Analysis of Variance
Body Weight
Brain Infarction / etiology,  prevention & control
Brain Ischemia / complications,  rehabilitation*
Disease Models, Animal
Exercise Test
Exercise Therapy / methods*
Gene Expression Regulation / physiology*
Hippocampus / metabolism*
Neurologic Examination
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate / metabolism*
Tetrazolium Salts / diagnostic use
Time Factors
Reg. No./Substance:
0/NR2B NMDA receptor; 0/Receptors, N-Methyl-D-Aspartate; 0/Tetrazolium Salts; 7OL20RET2I/triphenyltetrazolium

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