Document Detail


The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat.
MedLine Citation:
PMID:  20150577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: The magnitude of exercise-induced weight loss depends on the extent of compensatory responses. An increase in energy intake is likely to result from changes in the appetite control system toward an orexigenic environment; however, few studies have measured how exercise impacts on both orexigenic and anorexigenic peptides. OBJECTIVE: The aim of the study was to investigate the effects of medium-term exercise on fasting/postprandial levels of appetite-related hormones and subjective appetite sensations in overweight/obese individuals. DESIGN AND SETTING: We conducted a longitudinal study in a university research center. PARTICIPANTS AND INTERVENTION: Twenty-two sedentary overweight/obese individuals (age, 36.9 +/- 8.3 yr; body mass index, 31.3 +/- 3.3 kg/m(2)) took part in a 12-wk supervised exercise programme (five times per week, 75% maximal heart rate) and were requested not to change their food intake during the study. MAIN OUTCOME MEASURES: We measured changes in body weight and fasting/postprandial plasma levels of glucose, insulin, total ghrelin, acylated ghrelin (AG), peptide YY, and glucagon-like peptide-1 and feelings of appetite. RESULTS: Exercise resulted in a significant reduction in body weight and fasting insulin and an increase in AG plasma levels and fasting hunger sensations. A significant reduction in postprandial insulin plasma levels and a tendency toward an increase in the delayed release of glucagon-like peptide-1 (90-180 min) were also observed after exercise, as well as a significant increase (127%) in the suppression of AG postprandially. CONCLUSIONS: Exercise-induced weight loss is associated with physiological and biopsychological changes toward an increased drive to eat in the fasting state. However, this seems to be balanced by an improved satiety response to a meal and improved sensitivity of the appetite control system.
Authors:
C Martins; B Kulseng; N A King; J J Holst; J E Blundell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-11
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1609-16     Citation Subset:  AIM; IM    
Affiliation:
Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway. catia.martins@ntnu.no
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anaerobic Threshold / physiology
Anthropometry
Appetite / physiology*
Appetite Regulation / physiology*
Body Composition / physiology
Body Mass Index
Eating
Exercise Therapy*
Feeding Behavior / physiology*
Female
Food Habits
Humans
Insulin Resistance / physiology
Male
Middle Aged
Motivation*
Obesity / metabolism,  therapy
Overweight / metabolism,  therapy
Peptide Hormones / physiology*
Physical Fitness
Weight Loss / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
BBS/B/05079//Biotechnology and Biological Sciences Research Council
Chemical
Reg. No./Substance:
0/Peptide Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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