Document Detail

Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight.
MedLine Citation:
PMID:  20580657     Owner:  NLM     Status:  MEDLINE    
Eucommia ulmoides Oliver leaf extracts (ELE) have been shown to exert a hypolipidemic effect in hamsters. Therefore, it was hypothesized that ELE might affect lipid metabolism via changes in autonomic nerve activities and causes changes in thermogenesis and body weight. We examined this hypothesis, and found that intraduodenal (ID) injection of ELE elevated epididymal white adipose tissue sympathetic nerve activity (WAT-SNA) and interscapular brown adipose tissue sympathetic nerve activity (BAT-SNA) in urethane-anesthetized rats and elevated the plasma concentration of free fatty acids (FFA) (a marker of lipolysis) and body temperature (BT) (a marker of thermogenesis) in conscious rats. Furthermore, it was observed that ID administration of ELE decreased gastric vagal nerve activity (GVNA) in urethane-anesthetized rats, and that ELE given as food reduced food intake, body and abdominal adipose tissue weights and decreased plasma triglyceride level. These findings suggest that ELE stimulates lipolysis and thermogenesis through elevations in WAT-SNA and BAT-SNA, respectively, suppresses appetite by inhibiting the activities of the parasympathetic nerves innervating the gastrointestinal tract, including GVNA, and decreases the amount of abdominal fat and body weight via these changes.
Yuko Horii; Mamoru Tanida; Jiao Shen; Tetsuya Hirata; Naomi Kawamura; Atsunori Wada; Katsuya Nagai
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Publication Detail:
Type:  Journal Article     Date:  2010-05-16
Journal Detail:
Title:  Neuroscience letters     Volume:  479     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  181-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
ANBAS Corporation, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan.
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MeSH Terms
Adipose Tissue, Brown / drug effects,  innervation
Adipose Tissue, White / drug effects,  innervation
Body Temperature / drug effects*
Body Weight / drug effects*
Eating / drug effects*
Lipolysis / drug effects*
Plant Extracts / pharmacology*
Stomach / innervation
Sympathetic Nervous System / drug effects,  physiology*
Vagus Nerve / drug effects*,  physiology
Reg. No./Substance:
0/Plant Extracts

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