| Effects of Escherichia coli and Porphyromonas gingivalis lipopolysaccharide on pregnancy outcome in the golden hamster. | |
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MedLine Citation:
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PMID: 7927735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes the effects of two gram-negative bacterial endotoxin (lipopolysaccharide [LPS]) preparations on hamster pregnancy outcome variables. Single intravenous challenges with Escherichia coli and Porphyromonas gingivalis LPS on day 8 of pregnancy produced dose-dependent effects on fetal weight malformation and fetal resorption with E. coli LPS having potent embryolethal effects. Premating maternal exposure to P. gingivalis produced embryolethal effects similar to those of E. coli. These data suggest that maternal exposure to P. gingivalis LPS prior to and during pregnancy can induce deleterious effects on the developing fetus. |
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Authors:
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J G Collins; M A Smith; R R Arnold; S Offenbacher |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Infection and immunity Volume: 62 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1994-11-04 Completed Date: 1994-11-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4652-5 Citation Subset: IM |
Affiliation:
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School of Dentistry, Dental Research Center, University of North Carolina at Chapel Hill 27599-7455. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology Animals Cricetinae Escherichia coli / pathogenicity* Female Fetal Death / etiology Fetus / drug effects* Lipopolysaccharides / toxicity* Mesocricetus Porphyromonas gingivalis / pathogenicity* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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1K15DB00284//PHS HHS; 1R01HD26652/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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