Document Detail

Effects of Erwinia-asparaginase on the coagulation system.
MedLine Citation:
PMID:  7493674     Owner:  NLM     Status:  MEDLINE    
L-Asparaginase treatment during induction therapy in acute lymphoblastic leukaemia (ALL) is known to be frequently complicated by thromboembolic events. It was recently suggested that L-asparaginase derived from Erwinia chrysanthemi alters the coagulation system less severely than does Escherichia coli asparaginase. In a series of 11 adult patients with ALL, we investigated some parameters of the coagulation system during treatment with Erwinia asparaginase. The doses employed were rather high; all patients below the age of 60 years received 15,000 U/m2 daily over 14 days. In accordance with what is known from treatment with E. coli asparaginase, we observed significant lowering of antithrombin as well as of fibrinogen. However, as to fibrinogen indeed a significant decrease had occurred prior to the institution of Erwinia asparaginase treatment. The most striking observation in the present study was that the levels of prothrombin complex, reflecting the function of K-vitamin dependent coagulation factors II, VII and X, remained within normal ranges during treatment. This indicates that these coagulation factors were not affected by Erwinia asparaginase, an observation at variance with several reports where E. coli asparaginase was investigated. This latter observation was the only finding which could lend support to the view that Erwinia asparaginase affects the coagulation system less than E. coli asparaginase. Finally, one of our patients developed a sinus thrombosis, a severe thrombotic complication.
H Carlsson; D Stockelberg; L Tengborn; I Braide; J Carneskog; J Kutti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of haematology     Volume:  55     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-01-11     Completed Date:  1996-01-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
Department of Medicine, Sahlgren's Hospital, University of Göteborg, Sweden.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Asparaginase / adverse effects*
Blood Coagulation / drug effects*
Erwinia / enzymology
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Thrombosis / chemically induced*
Reg. No./Substance:
0/Antineoplastic Agents; EC

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