| Effects of Eriobotrya japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis. | |
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MedLine Citation:
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PMID: 20487204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Non-alcoholic steatohepatitis is associated with the deposition of lipid droplets in the liver, and is characterised histologically by the infiltration of inflammatory cells, hepatocellular degeneration and liver fibrosis. Oxidative stress may play an important role in the onset and deterioration of non-alcoholic steatohepatitis. We previously reported that an Eriobotrya japonica seed extract, extracted in 70% ethanol, exhibited antioxidant actions in vitro and in vivo. In this study, we examined the effect of this extract in a rat model of non-alcoholic steatohepatitis. METHODS: The seed extract was given in the drinking water to fats being fed a methionine-choline-deficient diet for 15 weeks. KEY FINDINGS: Increases in alanine aminotransferase and aspartate aminotransferase levels were significantly inhibited in rats fed the seed extract compared with the group on the diet alone. Formation of fatty droplets in the liver was also inhibited. Antioxidant enzyme activity in liver tissue was higher than in the diet-only group and lipid peroxidation was reduced compared with rats that also received the extract. Expression of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal was lower in the rats given the seed extract than in the diet-only group. In the former, liver tissue levels of transforming growth factor-beta and collagen were also decreased. CONCLUSIONS: Thus, the E. japonica seed extract inhibited fatty liver, inflammation and fibrosis, suggesting its usefulness in the treatment of non-alcoholic steatohepatitis. |
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Authors:
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Saburo Yoshioka; Atsuhide Hamada; Kohei Jobu; Junko Yokota; Masahide Onogawa; Shojiro Kyotani; Mitsuhiko Miyamura; Toshiji Saibara; Saburo Onishi; Yutaka Nishioka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 62 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-10-28 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 241-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, Kochi Medical School, Nankoku, Kochi, Japan. jm-saburo@kochi-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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metabolism Animals Antioxidants / isolation & purification, pharmacology, therapeutic use* Body Weight / drug effects Deoxyguanosine / analogs & derivatives, biosynthesis Disease Models, Animal Eriobotrya / chemistry* Fatty Liver / drug therapy*, etiology, metabolism, pathology Liver / drug effects*, metabolism, pathology Liver Cirrhosis, Experimental / etiology, metabolism, pathology, prevention & control Liver Function Tests Male Organ Size / drug effects Oxidative Stress / drug effects* Plant Extracts / isolation & purification, pharmacology, therapeutic use* Rats Rats, Wistar Seeds / chemistry Transforming Growth Factor beta / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/8-hydroxy-2'-deoxyguanosine; 0/Aldehydes; 0/Antioxidants; 0/Plant Extracts; 0/Transforming Growth Factor beta; 29343-52-0/4-hydroxy-2-nonenal; 961-07-9/Deoxyguanosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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