Document Detail

Effects of Enterococcus sp. isolated from deep seawater on inhibition of allergic responses in mice.
MedLine Citation:
PMID:  19079946     Owner:  NLM     Status:  MEDLINE    
The objective of the present study was to assess the effects of Enterococcus sp. strain TN-3 isolated from deep seawater on inhibition of eosinophil accumulation, IgE production and active cutaneous anaphylaxis (ACA). We investigated the effects of viable and non-viable TN-3 on allergen-induced peritoneal eosinophil accumulation in mice. Viable (5.4 x 1010 colony-forming units per 60 mg) or non-viable TN-3 (60 mg) was orally administered to BALB/c mice that had been sensitised with the cedar pollen (Cryptomeria japonica) allergen. Oral administration of non-viable TN-3 was effective in suppressing eosinophil accumulation while viable TN-3 was ineffective. We also examined the dose-response relationship for non-viable TN-3 in regard to eosinophil accumulation, IgE production and ACA in allergen-primed mice. Non-viable TN-3 was orally administered at doses of 15 mg (low dose), 30 mg (medium dose) and 60 mg (high dose) to BALB/c mice that had been sensitised with cedar pollen allergen. The anti-allergic effects expressed as inhibition of eosinophil accumulation, IgE production and ACA were found at the low and high doses, but not at the medium dose. These results suggest that non-viable TN-3 exhibited anti-allergic effects at doses of 15 and 60 mg.
Masatoshi Kondoh; Atsushi Hayashi; Mariko Okamori; Chie Motonaga; Tadao Enomoto; Lei Cheng; Takashi Shimada
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Publication Detail:
Type:  Journal Article     Date:  2008-12-16
Journal Detail:
Title:  The British journal of nutrition     Volume:  102     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-7     Citation Subset:  IM    
Central Research Laboratories, Nichinichi Pharmaceutical Corporation Ltd, 518-1417 Mie, Japan.
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MeSH Terms
Allergens / administration & dosage
Anaphylaxis / immunology
Anti-Allergic Agents / administration & dosage*
Antigens, Bacterial / administration & dosage*
Dose-Response Relationship, Drug
Enterococcus faecium / immunology*
Eosinophils / immunology
Hypersensitivity, Immediate / immunology,  prevention & control*
Immunoglobulin E / blood
Injections, Intraperitoneal
Leukocyte Count
Mice, Inbred BALB C
Microbial Viability / immunology
Models, Animal
Seawater / microbiology*
Water Microbiology
Reg. No./Substance:
0/Allergens; 0/Anti-Allergic Agents; 0/Antigens, Bacterial; 37341-29-0/Immunoglobulin E

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