| Effects of Endurance Exercise Training, Metformin, and their Combination on Adipose Tissue Leptin and IL-10 Secretion in OLETF Rats. | |
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MedLine Citation:
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PMID: 23019312 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Adipose tissue inflammation plays a role in cardiovascular (CV) and metabolic diseases associated with obesity, insulin resistance and type 2 diabetes mellitus (T2DM). The interactive effects of exercise training and metformin, two first-line T2DM treatments, on adipose tissue inflammation are not known. Using the hyperphagic, obese, insulin resistant Otsuka Long Evans Tokushima Fatty (OLETF) rat model, we tested the hypothesis that treadmill training, metformin, and/or their combination reduces the secretion of pro-inflammatory cytokines from adipose tissue. Compared to Long Evans Tokushima Otsuka (LETO) control rats (L-Sed), sedentary OLETF (O-Sed) animals secreted significantly greater amounts of leptin from retroperitoneal (RP) adipose tissue. Conversely, secretion of interleukin (IL)-10 by O-Sed adipose tissue was lower than that of L-Sed. Examination of leptin and IL-10 secretion from adipose tissue in OLETF groups treated with endurance exercise training (O-EndEx), metformin treatment (O-Met), and combined endurance training and metformin (O-E+M) from 20-32 wks of age indicated that (i) leptin secretion from adipose tissue was reduced in O-Met and O-E+M, but not O-EndEx; (ii) adipose tissue IL-10 secretion was increased in O-EndEx and O-E+M but not in O-Met; and (iii) only the combined treatment (O-E+M) displayed both a reduction in leptin secretion and an increase in IL-10 secretion. Leptin and IL-10 concentrations in adipose tissue-conditioned buffers were correlated with their plasma concentrations as well as with adipocyte diameters and total adiposity. Overall, this study indicates that exercise training and metformin have additive influences on adipose tissue secretion and plasma concentrations of leptin and IL-10. |
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Authors:
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Nathan T Jenkins; Jaume Padilla; Arturo A Arce-Esquivel; David S Bayless; Jeffrey Steven Martin; Heather J Leidy; Frank W Booth; R Scott Rector; Maurice Harold Laughlin |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Missouri. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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