Document Detail


Effects of Electrical Stimulation of the Hunger Center in the Lateral Hypothalamus and Food Reinforcement on Impulse Activity of the Stomach in Rabbits under Conditions of Hunger and Satiation.
MedLine Citation:
PMID:  23113291     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Stimulation of the lateral hypothalamus in preliminary fed animals in the presence of the food is associated with successful food-procuring behavior, accompanied by regular generation of high-amplitude slow electrical waves by muscles of the lesser curvature, body, and antrum of the stomach, which was reflected in the structure of temporal organization of slow electrical activity in the form of unimodal distribution of slow wave periods typical of satiation state. Despite increased level of food motivation caused by stimulation of the lateral hypothalamus, the additional food intake completely abolished the inhibitory effects of hunger motivation excitement on slow electrical muscle activity in the lesser curvature, body, and antrum of the stomach of satiated rabbits. Changes in slow electrical activity of the stomach muscles in rabbits deprived of food over 24 h and offered food and associated food-procuring behavior during electrical stimulation of the lateral hypothalamus have a two-phase pattern. Despite food intake during phase I of electrical stimulation, the downstream inhibitory effect of hunger motivation excitement on myogenic pacemaker of the lesser curvature of stomach abolishes the stimulating effect of food reinforcement on slow electrical muscle activity in the lesser curvature, body, and antrum of the stomach. During phase II of electrical stimulation, the food reinforcement decreases inhibitory effect of hunger motivation excitement on myogenic pacemaker of the lesser curvature that paces maximal rhythm of slow electrical waves for muscles activity in the lesser curvature, body, and antrum of the stomach, which is reflected by unimodal distribution of slow electrical wave periods. Our results indicated that the structure of temporal organization of slow electrical activity of the stomach muscles reflects convergent interactions of food motivation and reinforcement excitations on the dorsal vagal complex neurons in medulla oblongata.
Authors:
O Yu Zenina; A A Kromin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  153     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  808-15     Citation Subset:  IM    
Affiliation:
Department of Physiology, Tver' State Medical Academy, Federal Agency for Health Care and Social Development, Russia. krominaa@mail.ru.
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