Document Detail

Effects of early enteral feeding on fecal elastase 1 and plasma secretin.
MedLine Citation:
PMID:  20337981     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Enteral feeding is known to be effective on the development of gut hormone secretion and pancreatic exocrine function. The aim of the present study was to examine the effects of extremely early enteral feedings on the development in very low-birthweight (VLBW) infants.
METHODS: Fecal elastase 1 and plasma secretin concentrations were measured at four different periods during the first 28 days of life in VLBW infants, with extremely early enteral feeding starting within 24 h of birth, as well as in control infants.
RESULTS: Fecal concentrations of elastase 1 at 7, 14 and 28 days after birth were significantly higher than those at 1 or 2 days in both the early feeding and control groups. Fecal elastase 1 levels in the early feeding group were significantly higher than those in the control group at 7 and 14 days after birth. The plasma concentration of secretin at 14 days after birth was significantly higher than that at 1 or 2 days and 7 days after birth in the early feeding group. No significant differences in plasma secretin levels were detected between the early feeding and control groups at 1 or 2 days, 7 days and 28 days after birth, but a significant difference in secretin level was observed between the two groups at 14 days after birth.
CONCLUSIONS: Extremely early enteral feedings may play an important role in the development of pancreatic exocrine function and secretin secretion in the early period of life in VLBW infants.
Noritsugu Kaneko; Ken Hisata; Hiromichi Shoji; Kyoko Tanaka; Tomoyuki Nakazawa; Toshiaki Shimizu
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  52     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-10-20     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  607-10     Citation Subset:  IM    
Copyright Information:
© 2010 Japan Pediatric Society.
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Enteral Nutrition*
Feces / chemistry*
Infant Formula
Infant, Newborn
Infant, Very Low Birth Weight*
Milk, Human
Pancreatic Elastase / analysis*
Secretin / blood*
Reg. No./Substance:
1393-25-5/Secretin; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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