Document Detail


Effects of EG-VEGF, VEGF and TGF-β1 on pregnancy outcome in patients undergoing IVF-ET treatment.
MedLine Citation:
PMID:  22847371     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the correlation of endocrine gland-derived vascular endothelial growth factor (EG-VEGF), vascular endothelial growth factor (VEGF) and transforming growth factor beta 1 (TGF-β1) with the corresponding reproductive outcome in patients who received in vitro fertilization-embryo transfer (IVF-ET).
METHODS: Sixty-seven women undergoing IVF-ET at a university tertiary hospital were recruited for a prospective study. Concentrations of EG-VEGF, VEGF and TGF-β1 were measured by enzyme-linked immunosorbent assay (ELISA) in follicular fluid (FF) collected during oocyte retrieval (OR) and in serum collected 2 days after OR.
RESULTS: In FF, concentrations of both EG-VEGF and VEGF were negatively correlated with peak E2 and the number of MII oocytes retrieved, and positively correlated with each other. In serum, concentrations of all the three growth factors were positively correlated with the rate of good quality embryo, and with one another. Patients in the pregnancy group had lower peak E2 concentrations and higher serum EG-VEGF concentrations than those in the non-pregnancy group, but such tendency was not observed in the case of VEGF and TGF-β1.
CONCLUSIONS: Both concentrations of EG-VEGF and VEGF in FF were negatively correlated with ovarian response and oocyte maturation. Concentrations of all the three growth factors in serum were positively correlated with embryo quality, but only serum concentrations of EG-VEGF were associated with the pregnancy outcome.
Authors:
Min-zhi Gao; Xiao-ming Zhao; Yi Lin; Zhao-gui Sun; Hui-qin Zhang
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-31
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-03     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1091-6     Citation Subset:  IM    
Affiliation:
Shanghai Medical College of Fudan University, Shanghai 200032, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Embryo Transfer*
Estradiol / blood
Female
Fertilization in Vitro / methods*
Follicular Fluid / metabolism
Humans
Oocytes / physiology
Predictive Value of Tests
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Prospective Studies
Transforming Growth Factor beta1 / analysis*,  blood,  metabolism
Vascular Endothelial Growth Factor A / analysis*,  blood,  metabolism
Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / analysis*,  blood,  metabolism
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta1; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factor, Endocrine-Gland-Derived; 50-28-2/Estradiol
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