Document Detail


Effects of different doses of physical activity on C-reactive protein among women.
MedLine Citation:
PMID:  19952829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The purpose of this study was to examine the influence an exercise training program on CRP in postmenopausal women.
METHODS: Sedentary, overweight, or obese postmenopausal women with elevated systolic blood pressure (120-160 mm Hg; n = 464) were randomized into one of four groups: a nonexercise control or one of three aerobic exercise groups; exercise energy expenditure of 4, 8, or 12 kcal·kg(-1)·wk(-1) (KKW) for 6 months at a training intensity of 50% of peak VO2.
RESULTS: Complete data for 421 participants were available, and mean (SD) baseline CRP was 5.7 (5.5) mg·L(-1), with no significant differences across groups. Although VO2 increased in a dose-response manner, there were no significant changes in CRP in any of the exercise intervention groups compared with the control group. Change in fitness was not associated with change in CRP, whereas change in weight was significantly associated with change in CRP.
CONCLUSIONS: Despite increasing fitness, 6 months of aerobic exercise training did not improve CRP. However, improvements in CRP were associated with reductions in weight.
Authors:
Laura K Stewart; Conrad P Earnest; Steven N Blair; Timothy S Church
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  42     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-11-25     Completed Date:  2011-04-07     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  701-7     Citation Subset:  IM; S    
Affiliation:
The Cooper Institute.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00011193
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MeSH Terms
Descriptor/Qualifier:
C-Reactive Protein / analysis*
Exercise / physiology*
Female
Humans
Middle Aged
Obesity / metabolism
Overweight / metabolism
Oxygen Consumption / physiology
Physical Fitness
Postmenopause
Sedentary Lifestyle
Weight Loss
Grant Support
ID/Acronym/Agency:
HL071900/HL/NHLBI NIH HHS; HL66262/HL/NHLBI NIH HHS; R01 HL066262-01/HL/NHLBI NIH HHS; R01 HL071900-01/HL/NHLBI NIH HHS; R01 HL071900-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein
Comments/Corrections

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