| Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. | |
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MedLine Citation:
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PMID: 21030580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Little is known about the influence of dietary phosphate intake on fibroblast growth factor-23 (FGF23) and its subsequent effects on vitamin D levels. This study addresses changes in intact FGF23 (iFGF23) and C-terminal FGF23 (cFGF23), phosphaturia, and levels of vitamin D on high and low phosphate and calcium intake. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Ten healthy subjects adhered to a diet low or high in phosphate and calcium content for 36 hours each with a 1-week interval during which subjects adhered to their usual diet. Serum phosphate, calcium, vitamin D metabolites, parathyroid hormone (PTH), and FGF23 levels (cFGF23 and iFGF23) were measured several times a day. Phosphate, calcium, and creatinine excretion was measured in 24-hour urine on all study days. RESULTS: Serum phosphate levels and urinary phosphate increased during high dietary phosphate intake (from 1.11 to 1.32 mmol/L, P<0.0001 and 21.6 to 28.8 mmol/d, P=0.0005, respectively). FGF23 serum levels increased during high dietary phosphate/calcium intake (cFGF23 from 60 to 72 RU/ml, P<0.001; iFGF23 from 33 to 37 ng/L, P=0.003), whereas PTH declined. 1,25-dihydroxyvitamin D (1,25D) showed an inverse relation with FGF23. CONCLUSIONS: Variation in dietary phosphate and calcium intake induces changes in FGF23 (on top of a circadian rhythm) and 1,25D blood levels as well as in urinary phosphate excretion. These changes are detectable the day after the change in the phosphate content of meals. Higher FGF23 levels are associated with phosphaturia and a decline in 1,25D levels. |
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Authors:
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Marc G Vervloet; Frans J van Ittersum; Rahel M Büttler; Annemieke C Heijboer; Marinus A Blankenstein; Piet M ter Wee |
Publication Detail:
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Type: Journal Article Date: 2010-10-28 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 6 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-06-07 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 383-9 Citation Subset: IM |
Affiliation:
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VU University Medical Center, Department of Nephrology and Clinical Chemistry, PO Box 7057, 1007 MB Amsterdam, The Netherlands. m.vervloet@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / metabolism Calcium, Dietary / blood, metabolism*, urine Circadian Rhythm Cross-Over Studies Female Fibroblast Growth Factors / blood, metabolism*, urine Humans Male Netherlands Parathyroid Hormone / blood Phosphorus, Dietary / blood, metabolism*, urine Vitamin D / analogs & derivatives, blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Calcium, Dietary; 0/PTH protein, human; 0/Parathyroid Hormone; 0/Phosphorus, Dietary; 0/fibroblast growth factor 23; 1406-16-2/Vitamin D; 62031-54-3/Fibroblast Growth Factors; 66772-14-3/1,25-dihydroxyvitamin D |
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