Document Detail


Effects of diet-induced obesity and voluntary wheel running on bone properties in young male C57BL/6J mice.
MedLine Citation:
PMID:  20229059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both physical activity and body mass affect bone properties. In this study we examined how diet-induced obesity combined with voluntary physical activity affects bone properties. Forty 7-week-old male C57BL/6J mice were assigned to four groups evenly: control diet (C), control diet + running (CR), high-fat diet (HF, 60% energy from fat), and high-fat diet + running (HFR). After 21-week intervention, all mice were killed and the left femur was dissected for pQCT and mechanical measurements. Body mass increased 80% in HF and 62% in HFR, with increased epididymal fat pad weight and impaired insulin sensitivity. Except for total and trabecular volumetric bone mineral density (BMD), bone traits correlated positively with body mass, fat pad, leptin, and osteoprotegerin. Obesity induced by a high-fat diet resulted in increased femoral bone cross-sectional area, mineral content (BMC), polar moment of inertia, and mechanical parameters. Of the mice accessing the running wheel, those fed the control diet had thinner cortex and less total metaphyseal BMC and BMD, with enlarged metaphyseal marrow cavity, whereas mice fed the high-fat diet had significantly higher trabecular BMD and smaller marrow cavity. However, the runners had a weaker femoral neck as indicated by decreased maximum flexure load. These results suggest that voluntary running exercise affects bone properties in a site-specific manner and that there is a complex interaction between physical activity and obesity. Thus, both diet and exercise should be considered when optimizing the effects on body composition and bone, even though the underlying mechanisms remain partly unknown.
Authors:
Hongqiang Ma; Sira Torvinen; Mika Silvennoinen; Rita Rinnankoski-Tuikka; Heikki Kainulainen; Jukka Morko; Zhiqi Peng; Urho M Kujala; Paavo Rahkila; Harri Suominen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-13
Journal Detail:
Title:  Calcified tissue international     Volume:  86     ISSN:  1432-0827     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-9     Citation Subset:  IM    
Affiliation:
Department of Health Sciences, University of Jyväskylä, P.O. Box 35 (LL), 40014 Jyväskylä, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects,  metabolism
Animals
Biological Markers / blood
Body Weight / drug effects
Bone Density / drug effects,  physiology
Dietary Fats / administration & dosage,  adverse effects*
Femur / drug effects*,  metabolism,  radiography
Glucose Tolerance Test
Insulin / secretion
Leptin / blood
Male
Mice
Mice, Inbred C57BL
Motor Activity / drug effects*,  physiology
Obesity / blood,  chemically induced*,  physiopathology
Osteocalcin / blood
Osteoprotegerin / blood
Physical Conditioning, Animal / physiology
Stress, Mechanical
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Dietary Fats; 0/Leptin; 0/Osteoprotegerin; 104982-03-8/Osteocalcin; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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