| Effects of diet-induced obesity and voluntary wheel running on bone properties in young male C57BL/6J mice. | |
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MedLine Citation:
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PMID: 20229059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both physical activity and body mass affect bone properties. In this study we examined how diet-induced obesity combined with voluntary physical activity affects bone properties. Forty 7-week-old male C57BL/6J mice were assigned to four groups evenly: control diet (C), control diet + running (CR), high-fat diet (HF, 60% energy from fat), and high-fat diet + running (HFR). After 21-week intervention, all mice were killed and the left femur was dissected for pQCT and mechanical measurements. Body mass increased 80% in HF and 62% in HFR, with increased epididymal fat pad weight and impaired insulin sensitivity. Except for total and trabecular volumetric bone mineral density (BMD), bone traits correlated positively with body mass, fat pad, leptin, and osteoprotegerin. Obesity induced by a high-fat diet resulted in increased femoral bone cross-sectional area, mineral content (BMC), polar moment of inertia, and mechanical parameters. Of the mice accessing the running wheel, those fed the control diet had thinner cortex and less total metaphyseal BMC and BMD, with enlarged metaphyseal marrow cavity, whereas mice fed the high-fat diet had significantly higher trabecular BMD and smaller marrow cavity. However, the runners had a weaker femoral neck as indicated by decreased maximum flexure load. These results suggest that voluntary running exercise affects bone properties in a site-specific manner and that there is a complex interaction between physical activity and obesity. Thus, both diet and exercise should be considered when optimizing the effects on body composition and bone, even though the underlying mechanisms remain partly unknown. |
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Authors:
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Hongqiang Ma; Sira Torvinen; Mika Silvennoinen; Rita Rinnankoski-Tuikka; Heikki Kainulainen; Jukka Morko; Zhiqi Peng; Urho M Kujala; Paavo Rahkila; Harri Suominen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-13 |
Journal Detail:
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Title: Calcified tissue international Volume: 86 ISSN: 1432-0827 ISO Abbreviation: Calcif. Tissue Int. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905481 Medline TA: Calcif Tissue Int Country: United States |
Other Details:
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Languages: eng Pagination: 411-9 Citation Subset: IM |
Affiliation:
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Department of Health Sciences, University of Jyväskylä, P.O. Box 35 (LL), 40014 Jyväskylä, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects,
metabolism Animals Biological Markers / blood Body Weight / drug effects Bone Density / drug effects, physiology Dietary Fats / administration & dosage, adverse effects* Femur / drug effects*, metabolism, radiography Glucose Tolerance Test Insulin / secretion Leptin / blood Male Mice Mice, Inbred C57BL Motor Activity / drug effects*, physiology Obesity / blood, chemically induced*, physiopathology Osteocalcin / blood Osteoprotegerin / blood Physical Conditioning, Animal / physiology Stress, Mechanical Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Fats; 0/Leptin; 0/Osteoprotegerin; 104982-03-8/Osteocalcin; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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