| Effects of D1 and D2 antagonists on basal and apomorphine decreased body temperature in mice and rats. | |
| | |
MedLine Citation:
|
PMID: 2974995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In these experiments representative selective antagonists at D1 (SCH 23390) and D2 (haloperidol) receptors were studied for their effects on basal and apomorphine decreased body temperature in mice and rats. In mice, SCH 23390 (up to 3 mg/kg SC) neither affected basal body temperature nor blocked apomorphine-induced hypothermia (AIH). On the other hand, haloperidol alone was hypothermic and paradoxically also blocked AIH in mice. In rats, SCH 23390 alone produced hyperthermia; the mechanism by which this occurred is not known. SCH 23390 also blocked AIH in rats. However, the inhibition of AIH only occurred at doses of SCH 23390 that were themselves hyperthermic. Haloperidol did not alter basal body temperature but did block AIH in rats. These data suggest that apomorphine-induced body temperature changes are D2 mediated. |
| | |
Authors:
|
R E Chipkin |
Related Documents
:
|
3878705 - Influence of temperature on basal and induced hepatic monooxygenase activity in rats of... 2335965 - Reversible neural inactivation by cooling in anesthetized and freely behaving rats. 6685565 - Inhibition of shivering during restraint hypothermia. 9124495 - Operant control of ambient temperature during sleep deprivation. 756375 - Vascular reactivity to angiotensin and noradrenaline following nephrectomy in rats. 9804585 - Quantitation of intracellular [na+] in vivo by using tmdotp5- as an nmr shift reagent a... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 30 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1988 Jul |
Date Detail:
|
Created Date: 1989-02-23 Completed Date: 1989-02-23 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 683-6 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Schering-Plough Corporation, Bloomfield, NJ 07003. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apomorphine / pharmacology* Benzazepines / pharmacology* Body Temperature / drug effects* Dopamine Antagonists* Haloperidol / pharmacology* Hypothermia / chemically induced, physiopathology Male Mice Mice, Inbred Strains Rats Rats, Inbred Strains Receptors, Dopamine / drug effects, physiology Receptors, Dopamine D1 Receptors, Dopamine D2 Species Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Benzazepines; 0/Dopamine Antagonists; 0/Receptors, Dopamine; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 52-86-8/Haloperidol; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rosacea
Next Document: The D2 dopamine receptor agonist LY171555 induces catalepsy in the mouse.