| Effects of D-penicillamine on growth and cell cycle kinetics of cultured rabbit articular chondrocytes. | |
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MedLine Citation:
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PMID: 6712306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The long-acting antirheumatic drug D-penicillamine was found to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes. This inhibitory effect was dose-related between 5 X 10(-4) M and 5 X 10(-3) M and was time-dependent for a given dose. Flow cytometric analysis showed that drug exposure led to a slowdown in cell cycle progression. This was manifested as a decrease in the number of cells in S phase, due especially to an accumulation of cells in G0 G1 and also to a slight cessation of cell transit through G2 M. Recovery experiments showed that the effect is transitory and reversible. It is suggested that the articular chondrocyte is a target cell for D-penicillamine and that these cells have a D-penicillamine sensitive restriction point in the G0 G1 phase of the cell cycle and to a less extent in the G2 M phase. |
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Authors:
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P Jaffray; X Ronot; M Adolphe; J Fontagne; P Lechat |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 43 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-04 Completed Date: 1984-05-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 333-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cartilage, Articular / analysis, cytology, drug effects* Cell Cycle / drug effects Cell Division / drug effects Cells, Cultured Clone Cells / drug effects DNA / analysis Dose-Response Relationship, Drug Flow Cytometry Penicillamine / pharmacology* Rabbits |
| Chemical | |
Reg. No./Substance:
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52-67-5/Penicillamine; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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