Document Detail

Effects of D-amphetamine in a temporal discrimination procedure: selective changes in timing or rate dependency?
MedLine Citation:
PMID:  12216978     Owner:  NLM     Status:  MEDLINE    
Two experiments evaluated rate dependency and a neuropharmacological model of timing as explanations of the effects of amphetamine on behavior under discriminative control by time. Four pigeons pecked keys during 60-trial sessions. On each trial, the houselight was lit for a particular duration (5 to 30 s), and then the key was lit for 30 s. In Experiment 1, the key could be lit either green or blue. If the key was lit green and the sample was 30 s, or if the key was lit blue and the sample was 5 s, pecks produced food on a variable-interval 20-s schedule. The rate of key pecking increased as a function of sample duration when the key was green and decreased as a function of sample duration when the key was blue. Acute d-amphetamine (0.1 to 3.0 mg/kg) decreased higher rates of key pecking and increased lower rates of key pecking as predicted by rate dependency, but did not shift the timing functions leftward (toward overestimation) as predicted by the neuropharmacological model. These results were replicated in Experiment 2, in which the key was lit only one color during sessions, indicating that the effects were not likely due to disruption of discriminative control by key color. These results are thus consistent with rate dependency but not with the predictions of the neuropharmacological model.
Amy L Odum; Lori M Lieving; David W Schaai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the experimental analysis of behavior     Volume:  78     ISSN:  0022-5002     ISO Abbreviation:  J Exp Anal Behav     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-09     Completed Date:  2003-02-12     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  0203727     Medline TA:  J Exp Anal Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-214     Citation Subset:  IM    
Department of Psychology, University of New Hampshire 03824, USA.
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MeSH Terms
Behavior, Animal / drug effects
Dextroamphetamine / administration & dosage,  pharmacology*
Discrimination Learning / drug effects*
Dopamine Agents / administration & dosage,  pharmacology*
Drug Administration Schedule
Generalization (Psychology)
Random Allocation
Time Factors
Time Perception / drug effects*
Reg. No./Substance:
0/Dopamine Agents; 51-64-9/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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