Document Detail

Effects of Cyclosporin A on skin graft rejection in Xenopus.
MedLine Citation:
PMID:  9617585     Owner:  NLM     Status:  MEDLINE    
In Xenopus, it has been shown that semi-xenogeneic adult skin grafts usually render donor-specific tolerance to perimetamorphic larvae, while these skin grafts are never accepted in adults. The mechanisms operating in this tolerance induction are largely unclear. The present investigation was planned to test whether lower responsiveness of larvae to non-self antigens could be ascribable to perimetamorphic tolerance induction. We tried to induce tolerance in adults by treating them with Cyclosporin A (CsA), which is known to decline the immune system in mammals. The results showed that CsA-treated adults could never be rendered tolerant to semi-xenogeneic skin grafts, although the grafts were not rejected as long as the treatment was continued. We have also proposed a possibly different mechanisms for the rejection of semi-xenogeneic skin grafts and of full-xenogeneic skin grafts.
S Tozaki; S Tochinai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  22     ISSN:  0145-305X     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:    1998 Jan-Feb
Date Detail:
Created Date:  1998-08-26     Completed Date:  1998-08-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-90     Citation Subset:  IM    
Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan.
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MeSH Terms
Cyclosporine / pharmacology*
Graft Rejection / immunology*
Immune Tolerance
Immunosuppressive Agents / pharmacology*
Larva / immunology
Lymphocyte Activation
Metamorphosis, Biological / immunology
Skin Transplantation / immunology*
Spleen / cytology,  immunology
Xenopus / immunology*
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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