| Effects of Cushing disease on bone mineral density in a pediatric population. | |
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MedLine Citation:
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PMID: 20223476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate bone mineral density (BMD) in children with Cushing disease before and after transphenoidal surgery (TSS). STUDY DESIGN: Hologic dual-energy x-ray absorptiometry (DXA) scans of 35 children with Cushing disease were analyzed retrospectively. Sixteen of the 35 patients had follow-up DXA scans performed 13 to 18 months after TSS. BMD and bone mineral apparent density (BMAD) for lumbar spine (LS) L1 to L4 and femoral neck (FN) were calculated. RESULTS: Preoperatively, 38% and 23% of patients had osteopenia of the LS and FN, respectively. Both BMD and BMAD Z-scores of the LS were worse than those for the FN (-1.60 +/- 1.37 versus -1.04 +/- 1.19, P = .003), and (-1.90 +/- 1.49 versus -0.06 +/- 1.90, P < .001); postoperative improvement in BMD and BMAD were more pronounced in LS than in the FN (0.84 +/- 0.88 versus 0.15 +/- 0.62, P<.001; and 0.73 +/- 1.13 versus -0.26 +/- 1.21, P = .015). Pubertal stage, cortisol levels, and length of disease had no effect on BMD. CONCLUSIONS: In children with Cushing disease, vertebral BMD was more severely affected than femoral BMD and this effect was independent of degree or duration of hypercortisolism. BMD for the LS improved significantly after TSS; osteopenia in this group may be reversible. |
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Authors:
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Maya B Lodish; Hui-Pin Hsiao; Anastasios Serbis; Ninet Sinaii; Anya Rothenbuhler; Margaret F Keil; Sosipatros A Boikos; James C Reynolds; Constantine A Stratakis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-03-10 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 156 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-17 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 1001-5 Citation Subset: AIM; IM |
Copyright Information:
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Published by Mosby, Inc. |
Affiliation:
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Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD 20892, USA. lodishma@mail.nih.gov |
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adolescent Bone Density* Child Cushing Syndrome / physiopathology Female Femur / physiopathology Humans Hydrocortisone / blood, urine Male Pituitary ACTH Hypersecretion / physiopathology* Retrospective Studies Spine / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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Z99 HD999999/HD/NICHD NIH HHS; ZIA HD000642-12/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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