Document Detail

Effects of current size, postnatal growth, and birth size on blood pressure in early childhood.
MedLine Citation:
PMID:  21078732     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In a prospective study, we investigated the impact of early growth on blood pressure at 3 years of age.
METHODS: We measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) for 590 children 3 years of age and related measurements to current size and size at birth, 6 months, 1 year, and 2 years of age.
RESULTS: SBP was related positively to weight at 3 and 2 years and, after adjustment for current size, negatively to weight at birth and 6 months but not at 1 or 2 years. No effect was observed for DBP. A family history of hypertension was associated with higher maternal blood pressure, greater weight, and gestational hypertension (P = .05). Mothers with a history of gestational hypertension had higher SBP and DBP values (P < .001). In multivariate linear regression analyses, SBP was influenced positively by weight at 3 years and family history of hypertension and negatively by weight at 6 months. None of the factors was associated with DBP.
CONCLUSIONS: For 3-year-old children, current weight was a determinant of SBP and postnatal growth to 6 months of age was more predictive than birth weight. A family history of hypertension is important in determining maternal blood pressure. These observations suggest a window in which postnatal growth might be modified.
Peter C Hindmarsh; Sinead Bryan; Michael P P Geary; Tim J Cole
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-15
Journal Detail:
Title:  Pediatrics     Volume:  126     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-02-08     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1507-13     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight / physiology*
Blood Pressure / physiology*
Child, Preschool
Follow-Up Studies
Great Britain / epidemiology
Hypertension / epidemiology,  etiology,  physiopathology
Infant, Newborn
Prospective Studies
Risk Factors
Weight Gain / physiology*
Grant Support
G0700961//Medical Research Council; //British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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