| Effects of current size, postnatal growth, and birth size on blood pressure in early childhood. | |
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MedLine Citation:
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PMID: 21078732 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: In a prospective study, we investigated the impact of early growth on blood pressure at 3 years of age. METHODS: We measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) for 590 children 3 years of age and related measurements to current size and size at birth, 6 months, 1 year, and 2 years of age. RESULTS: SBP was related positively to weight at 3 and 2 years and, after adjustment for current size, negatively to weight at birth and 6 months but not at 1 or 2 years. No effect was observed for DBP. A family history of hypertension was associated with higher maternal blood pressure, greater weight, and gestational hypertension (P = .05). Mothers with a history of gestational hypertension had higher SBP and DBP values (P < .001). In multivariate linear regression analyses, SBP was influenced positively by weight at 3 years and family history of hypertension and negatively by weight at 6 months. None of the factors was associated with DBP. CONCLUSIONS: For 3-year-old children, current weight was a determinant of SBP and postnatal growth to 6 months of age was more predictive than birth weight. A family history of hypertension is important in determining maternal blood pressure. These observations suggest a window in which postnatal growth might be modified. |
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Authors:
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Peter C Hindmarsh; Sinead Bryan; Michael P P Geary; Tim J Cole |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-15 |
Journal Detail:
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Title: Pediatrics Volume: 126 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e1507-13 Citation Subset: AIM; IM |
Affiliation:
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UCL Institute of Child Health, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, 30 Guilford St, London WC1N 1EH, United Kingdom. p.hindmarsh@ucl.ac.uk |
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//British Heart Foundation |
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