Document Detail

Effects of a cross-linked hyaluronic acid based gel on the healing of open wounds in dogs.
MedLine Citation:
PMID:  23153045     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare effects of a cross-linked hyaluronic acid (HA) based gel (CMHA-S) to a standard wound management protocol on the healing of acute, full-thickness wounds in dogs.
STUDY DESIGN: A prospective, controlled, experimental study.
ANIMALS: Purpose-bred, adult, female beagles (n = 10).
METHODS: Two 2 × 2 cm wounds were surgically created bilaterally on the trunk of each dog and each side randomized to treatment (CMHA-S) or control (CON) groups. Total and open wound areas were measured with digital image planimetry at 15 time points. From these data, percent contraction and percent epithelialization were calculated. Tissue biopsies were obtained at 6 time points and histologic features were scored.
RESULTS: Total wound area was significantly larger and percent contraction was significantly less in CMHA-S compared to CON wounds at all data points between days 9 and 18. At day 25, and for the remainder of the study, CMHA-S wounds were smaller and contracted more than CON wounds, reaching significance at day 32. Percent epithelialization was significantly less in CMHA-S compared to CON wounds at all data points after day 11. Histologically, fibroblastic cellular infiltration was significantly higher in CMHA-S wounds at day 21.
CONCLUSIONS: CMHA-S wounds healed more slowly than CON wounds. This HA-based gel is not indicated in acute, full-thickness skin wounds in dogs as administered in this study. However, treatment may be beneficial in the mid-to-late repair stage of healing, or if scar minimization is desired. Further studies to evaluate the effects of the CMHA-S gel on canine wounds are indicated.
Heather S Hadley; Bryden J Stanley; Michele C Fritz; Joe G Hauptman; Barbara A Steficek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  42     ISSN:  1532-950X     ISO Abbreviation:  Vet Surg     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-07     Completed Date:  2013-08-20     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-9     Citation Subset:  IM    
Copyright Information:
© Copyright 2012 by The American College of Veterinary Surgeons.
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MeSH Terms
Bandages / veterinary
Dogs / injuries
Hyaluronic Acid / administration & dosage,  therapeutic use*
Skin / injuries,  pathology,  physiopathology
Time Factors
Treatment Outcome
Wound Healing / drug effects*,  physiology
Reg. No./Substance:
0/Gels; 9004-61-9/Hyaluronic Acid
Comment In:
Vet Surg. 2014 Feb;43(2):227   [PMID:  24491235 ]
Vet Surg. 2014 Feb;43(2):227

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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