| Effects of Creatine and Exercise on Skeletal Muscle of FRG1-Transgenic Mice. | |
| | |
MedLine Citation:
|
PMID: 22343158 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: The FRG1-transgenic mouse displays muscle dysfunction and atrophy reminiscent of fascioscapulohumeral muscular dystrophy (FSHD) and could provide a model to determine potential therapeutic interventions. Methods: To determine if FRG1 mice benefit from treatments that improve muscle mass and function, mice were treated with creatine alone (Cr) or in combination with treadmill exercise (CrEX). Results: The CrEx treatment increased quadriceps weight, mitochondrial content (cytochome c oxidase (COX) activity, COX subunit one and four protein), and induced greater improvements in grip strength and rotarod fall speed. While Cr increased COX subunits one and four protein, no effect on muscle mass or performance was found. Since Cr resulted in no functional improvements, the benefits of CrEx may be mediated by exercise; however, the potential synergistic action of the combined treatment cannot be excluded. Conclusion: Treatment with CrEx attenuates atrophy and muscle dysfunction associated with FRG1 overexpression. These data suggest exercise and creatine supplementation may benefit individuals with FSHD. |
| | |
Authors:
|
Daniel I Ogborn; Katelyn J Smith; Justin D Crane; Adeel Safdar; Bart P Hettinga; Rossella Tupler; Mark A Tarnopolsky |
Related Documents
:
|
10956358 - Nasal resistance and flow resistive work of nasal breathing during exercise: effects of... 22073428 - Non-exercise physical activity in agricultural and urban people. 16558338 - Oxygenation and exercise performance-enhancing effects attributed to the breathe-right ... 16539308 - Quantification of ciliary beat frequency in sinonasal epithelial cells using differenti... 23258478 - Cardiac magnetic resonance imaging: a new gold standard for ventricular volume quantifi... 9187608 - Noninvasive determination of cardiac output in a model of acute lung injury. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 39 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
|
Languages: eng Pagination: 225-31 Citation Subset: IM |
Affiliation:
|
Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel PLP1 mutation further expands the clinical heterogeneity at the locus.
Next Document: Serum-Positive and -Negative AQP4 Antibody NMO in Chinese Patients.