Document Detail


Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension.
MedLine Citation:
PMID:  20844075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Consumption of flavonoid-containing foods may be useful for the management of hypertension.
OBJECTIVE: We investigated whether 100% Concord grape juice lowers blood pressure in patients with prehypertension and stage 1 hypertension.
DESIGN: We conducted a double-blind crossover study to compare the effects of grape juice (7 mL · kg⁻¹ · d⁻¹) and matched placebo beverage on 24-h ambulatory blood pressure, stress-induced changes in blood pressure, and biochemical profile. Participants consumed each beverage for 8 wk with a 4-wk rest period between beverages. They ceased consumption of grapes and other flavonoid-containing beverages throughout the study.
RESULTS: We enrolled 64 otherwise healthy patients taking no antihypertensive medications (31% women, 42% black, age 43 ± 12 y). Baseline mean (± SD) cuff blood pressure was 138 ± 7 (systolic)/82 ± 7 (diastolic) mm Hg. No effects on the primary endpoint of 24-h mean systolic blood pressure, diastolic blood pressure, or stress-induced changes in blood pressure were observed. A secondary endpoint was nocturnal dip in systolic pressure. At baseline, nocturnal pressure was 8.3 ± 7.1% lower at night than during daytime. The mean nocturnal dip increased 1.4 percentage points after grape juice and decreased 2.3 percentage points after placebo (P = 0.005). Fasting blood glucose was 91 ± 10 mg/dL at baseline for the entire cohort. Glucose decreased 2 mg/dL after consumption of grape juice and increased 1 mg/dL after consuming the placebo (P = 0.03).
CONCLUSIONS: We observed no effect of grape juice on ambulatory blood pressure in this cohort of relatively healthy individuals with modestly elevated blood pressure. Secondary analyses suggested favorable effects on nocturnal dip and glucose homeostasis that may merit further investigation. This trial was registered at clinicaltrials.gov as NCT00302809.
Authors:
Mustali M Dohadwala; Naomi M Hamburg; Monika Holbrook; Brian H Kim; Mai-Ann Duess; Aaron Levit; Megan Titas; William B Chung; Felix B Vincent; Tara L Caiano; Alissa A Frame; John F Keaney; Joseph A Vita
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-09-15
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-11-09     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1052-9     Citation Subset:  AIM; IM    
Affiliation:
Evans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00302809
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / pharmacology,  therapeutic use*
Blood Glucose / metabolism*
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory
Cross-Over Studies
Double-Blind Method
Female
Humans
Hypertension / blood,  drug therapy*
Male
Middle Aged
Phytotherapy*
Plant Preparations / pharmacology,  therapeutic use*
Vitis*
Grant Support
ID/Acronym/Agency:
HL081587/HL/NHLBI NIH HHS; HL083269/HL/NHLBI NIH HHS; HL083801/HL/NHLBI NIH HHS; HL75795/HL/NHLBI NIH HHS; K12 HL083781/HL/NHLBI NIH HHS; M01RR00533/RR/NCRR NIH HHS; T32 HL 07224/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Blood Glucose; 0/Plant Preparations
Comments/Corrections

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