Document Detail


Effects of Compounds from Passiflora edulis Sims f. flavicarpa Juice on Blood Coagulation and on Proteolytic Enzymes.
MedLine Citation:
PMID:  22486645     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Passion fruit (Passiflora edulis Sims f. flavicarpa) is popularly known for its sedative and calming properties and is consumed as a fresh fruit or as a juice. The clinical observation of blood incoagulability associated with excessive consumption of passion fruit juice, in a patient treated with warfarin, prompted the current study to investigate in vitro the presence of blood clotting inhibitors in Passiflora edulis Sims f. flavicarpa extract. After purification process, two compounds of distinct molecular weight and inhibitory action were better characterized. One is a trypsin inhibitor similar to inhibitors from Bowman-Birk family, named PeTI-I12, and other is a compound active in coagulation that prolongs aPTT and PT, but does not change TT. The aim of this study is to provide evidence that passion fruit extract's components play a role on hemostasis and therefore may be relevant in the handling of patients treated with anticoagulants or suffering hemorrhagic diseases.
Authors:
Ana Claudia Sato; Sonia A Andrade; Marlon V Brito; Antonio Miranda; Misako Uemura Sampaio; Francisco Humberto de Abreu Maffei; Maria Luiza Vilela Oliva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Protein and peptide letters     Volume:  19     ISSN:  1875-5305     ISO Abbreviation:  Protein Pept. Lett.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441434     Medline TA:  Protein Pept Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  501-8     Citation Subset:  IM    
Affiliation:
Universidade Federal de Sao Paulo-Escola Paulista de Medicina, Departamento de Bioquimica, Rua Tres de Maio, 100, 04044-020 Sao Paulo, SP, Brazil. olivaml.bioq@epm.br.
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