Document Detail

Effects of Co-Administration of Estrogen and Androgen on Induction of Sex Reversal in the Medaka Oryzias latipes.
MedLine Citation:
PMID:  21557659     Owner:  NLM     Status:  In-Data-Review    
To investigate how estrogen and androgen affect each other in inducing sex reversal in the medaka, O. Iatipes, 17β-estradiol (E2) and 17α-methyldihydrotestosterone (MDHT) were co-administered by a convenient method for hormonal treatment, in which freshly fertilized eggs were immersed for 24 h in saline containing either or both of the two sex steroids in different concentrations and/or ratios. The minimal concentrations of E2 and MDHT sufficient to induce the maximal rate of sex reversal from male to female and from female to male were 500 ng/ml and 2.5 ng/ml, respectively, both of which were referred to as the most efficacious dose (MED), and each equivalent for the inducing potency in sex reversal. E2 and MDHT, when simultaneously administered at MED, greatly suppressed each other to induce each corresponding sex reversal. Thus, the present experimental results indicate that E2 and DMHT are antagonists that induce corresponding sex reversal, and suggest that genotypic sex in the medaka might be modified through an unknown factor of common affinity to both sex steroids, by which the pathway of differentiation of either sex could be switched at the early stages of development far before gonadal sex differentiation.
Hirokuni Kobayashi; Takashi Iwamatsu; Yasushi Shibata; Michio Ishihara; Yasuhisa Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zoological science     Volume:  28     ISSN:  0289-0003     ISO Abbreviation:  Zool. Sci.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702287     Medline TA:  Zoolog Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  355-9     Citation Subset:  IM    
1 Department of Biology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan.
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