Document Detail

Effects of clozapine on heart rate dynamics and their relationship with therapeutic response in treatment-resistant schizophrenia.
MedLine Citation:
PMID:  23277266     Owner:  NLM     Status:  MEDLINE    
Previous studies have suggested the utility of nonlinear complexity measures of heart rate variability (HRV) in evaluating the regulatory capacity of the neuroautonomic system. The purpose of the present study was to investigate the effects of clozapine on the nonlinear complexity measures of HRV in patients with treatment-resistant schizophrenia to find novel electrophysiological markers that indicate response to clozapine treatment. Forty patients with treatment-resistant schizophrenia were evaluated during 8 weeks of clozapine monotherapy. For nonlinear complexity measures of HRV, the approximate entropy (ApEn) and sample entropy (SampEn) values were obtained. The response rate to clozapine was 37.5%. The results of multivariate analysis of covariance revealed that the ApEn and the SampEn values of HRV at week 8 were significantly higher in the responders than in the nonresponders. Repeated-measures analysis of covariance showed a significant group by time interaction effect in the ApEn and SampEn indices. The responder group showed an increasing pattern of change in these complexity measures after administration of clozapine, whereas the nonresponder group showed a decreasing pattern of change. These results suggest that the nonlinear dynamic complexity measures of HRV, which indicate the irregularity and complexity of the biosystem, may be useful in evaluating the therapeutic changes of neuroautonomic function in schizophrenia. The response to clozapine treatment is expected to be more favorable when the plasticity of the neuroautonomic system reflected in the nonlinear complexity measures is high.
Jong-Hoon Kim; Sang Hoon Yi; Jinyoung Lee; Yong Sik Kim
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  33     ISSN:  1533-712X     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-06-12     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Department of Psychiatry, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.
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MeSH Terms
Antipsychotic Agents / adverse effects,  therapeutic use*
Clozapine / adverse effects,  therapeutic use*
Drug Resistance*
Heart Rate / drug effects*
Logistic Models
Multivariate Analysis
Nonlinear Dynamics
Predictive Value of Tests
Prospective Studies
Psychiatric Status Rating Scales
Republic of Korea
Schizophrenia / diagnosis,  drug therapy*,  physiopathology
Schizophrenic Psychology*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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