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Effects of Cisplatin in neuroblastoma rat cells: damage to cellular organelles.
MedLine Citation:
PMID:  22505928     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated. In particular it has been shown that some organelles are cisPt target and are involved in cell death. This paper aims to describe the morphological and functional changes of the Golgi apparatus and lysosomes during apoptosis induced in neuronal rat cells (B50) by cisplatin. The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death.
Authors:
Giada Santin; Luigi Scietti; Paola Veneroni; Sergio Barni; Graziella Bernocchi; Maria Grazia Bottone
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Publication Detail:
Type:  Journal Article     Date:  2012-02-28
Journal Detail:
Title:  International journal of cell biology     Volume:  2012     ISSN:  1687-8884     ISO Abbreviation:  Int J Cell Biol     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517861     Medline TA:  Int J Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424072     Citation Subset:  -    
Affiliation:
Istituto di Genetica Molecolare, CNR, 27100 Pavia, Italy.
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