Document Detail

Effects of Chrysanthemum indicum Linn. on coronary, vertebral, renal and aortic blood flows of the anesthetized dog.
MedLine Citation:
PMID:  3579429     Owner:  NLM     Status:  MEDLINE    
The hemodynamic effects of the water extract of flower of Chrysanthemum indicum Linn. (CIL) and adenosine were examined in anesthetized open-chest dogs by measuring simultaneously and continuously coronary (CBF), vertebral (VBF), renal (RBF) and aortic blood flows (AoF). Intravenous administration of CIL (5-20 mg/kg) as well as adenosine (10-50 micrograms/kg) produced decreases in aortic blood pressure (AoP) and RBF, and increases in AoF, VBF, CBF and left ventricular dP/dt (LVdP/dt). Calculated coronary, vertebral and total peripheral resistances were decreased by CIL or adenosine in a dose-dependent manner. The ratio (1.69 +/- 0.27) of decrease in coronary vascular resistance to that in total peripheral resistance by CIL (10 mg/kg) was apparently smaller than that (4.03 +/- 0.48) by adenosine (10 micrograms/kg). After beta-adrenergic blockade, increases in AoF and LVdP/dt were inhibited, but decreases in AoP and coronary, vertebral and total peripheral resistances and increase in renal vascular resistance were not changed. These results indicate that CIL directly and uniformly produces coronary and systemic vasodilation with renal vasoconstriction, and that adenosine directly produces vasoconstriction in renal vasculature and vasodilation which is more potent in coronary vasculature than in systemic ones.
T Kato; K Noguchi; Y Miyamoto; M Suekawa; M Aburada; E Hosoya; M Sakanashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  285     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-06-08     Completed Date:  1987-06-08     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  288-300     Citation Subset:  IM    
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MeSH Terms
Adenosine / pharmacology
Cerebrovascular Circulation / drug effects
Chrysanthemum cinerariifolium*
Coronary Circulation / drug effects
Heart Rate / drug effects
Plant Extracts / pharmacology*
Propranolol / pharmacology
Regional Blood Flow / drug effects*
Renal Circulation / drug effects
Vascular Resistance / drug effects
Vertebral Artery / drug effects
Reg. No./Substance:
0/Plant Extracts; 525-66-6/Propranolol; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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