| Effects of chronic oral rimonabant administration on energy budgets of diet-induced obese C57BL/6 mice. | |
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MedLine Citation:
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PMID: 22173576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The endocannabinoids have been recognized as an important system involved in the regulation of energy balance. Rimonabant (SR141716), a selective inverse agonist of cannabinoid receptor 1 (CB1), has been shown to cause weight loss. However, its suppressive impact on food intake is transient, indicating a likely additional effect on energy expenditure. To examine the effects of rimonabant on components of energy balance, we administered rimonabant or its vehicle to diet-induced obese (DIO) C57BL/6 mice once daily for 30 days, by oral gavage. Rimonabant induced a persistent weight reduction and a significant decrease in body fatness across all depots. In addition to transiently reduced food intake, rimonabant-treated mice exhibited decreased apparent energy absorption efficiency (AEAE), reduced metabolizable energy intake (MEI), and increased daily energy expenditure (DEE) on days 4-6 of treatment. However, these effects on the energy budget had disappeared by days 22-24 of treatment. No chronic group differences in resting metabolic rate (RMR) or respiratory quotient (RQ) (P > 0.05) were detected. Rimonabant treatment significantly increased daily physical activity (PA) levels both acutely and chronically. The increase in PA was attributed to elevated activity during the light phase but not during the dark phase. Taken together, these data suggested that rimonabant caused a negative energy balance by acting on both energy intake and expenditure. In the short term, the effect included both reduced intake and elevated PA but the chronic effect was only on increased PA expenditure. |
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Authors:
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Li-Na Zhang; Yuko Gamo; Rachel Sinclair; Sharon E Mitchell; David G Morgan; John C Clapham; John R Speakman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-12-15 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 20 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-26 Completed Date: 2012-07-26 Revised Date: 2012-08-13 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 954-62 Citation Subset: IM |
Affiliation:
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Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects* Administration, Oral Animals Anti-Obesity Agents / administration & dosage, pharmacology* Eating / drug effects* Energy Intake / drug effects* Energy Metabolism / drug effects* Male Mice Mice, Inbred C57BL Mice, Obese Obesity / blood, drug therapy* Piperidines / administration & dosage, pharmacology* Pyrazoles / administration & dosage, pharmacology* Receptors, Cannabinoid / antagonists & inhibitors* Weight Loss / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Piperidines; 0/Pyrazoles; 0/Receptors, Cannabinoid; 158681-13-1/rimonabant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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