Document Detail


Effects of chronic buspirone treatment on cocaine self-administration.
MedLine Citation:
PMID:  23072835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cocaine abuse and dependence is a major public health problem that continues to challenge medication-based treatment. Buspirone (Buspar) is a clinically available, non-benzodiazepine anxiolytic medication that acts on both serotonin and dopamine systems. In recent preclinical studies, acute buspirone treatment reduced cocaine self-administration at doses that did not also decrease food-reinforced behavior in rhesus monkeys (Bergman et al, 2012). The present study evaluated the effectiveness of chronic buspirone treatment on self-administration of cocaine and food. Five adult rhesus monkeys (Macaca mulatta) were trained to self-administer cocaine and food during four 1-h daily sessions under a second-order schedule of reinforcement (FR2 [VR 16:S]). Buspirone (0.32 and 0.56 mg/kg/h) was administered intravenously through one lumen of a double-lumen catheter every 20 min for 23 h each day for 7-10 consecutive days. Each buspirone treatment period was followed by saline control treatment until drug- and food-maintained responding returned to baseline levels. Buspirone significantly reduced responding maintained by cocaine, and shifted the dose-effect curve downwards. Buspirone had minimal effects on food-maintained responding. In cocaine discrimination studies, buspirone (0.1-0.32 mg/kg, IM) did not antagonize the discriminative stimulus and rate-altering effects of cocaine in four of six monkeys. These findings indicate that buspirone selectively attenuates the reinforcing effects of cocaine in a nonhuman primate model of cocaine self-administration, and has variable effects on cocaine discrimination.
Authors:
Nancy K Mello; Peter A Fivel; Stephen J Kohut; Jack Bergman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-17
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  38     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-10-17     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  455-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Anxiety Agents / administration & dosage*
Behavior, Addictive / prevention & control*,  psychology
Buspirone / administration & dosage*
Cocaine / administration & dosage*,  antagonists & inhibitors
Eating / drug effects*,  physiology,  psychology
Macaca mulatta
Male
Self Administration
Treatment Outcome
Grant Support
ID/Acronym/Agency:
R01 DA002519/DA/NIDA NIH HHS; R01 DA026892/DA/NIDA NIH HHS; R01-DA002519/DA/NIDA NIH HHS; R01-DA026892/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; I5Y540LHVR/Cocaine; TK65WKS8HL/Buspirone
Comments/Corrections

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