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Effects of Chloramphenicol on the Circadian Rhythm of Neurospora crassa.
MedLine Citation:
PMID:  16659724     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Chloramphenicol, an inhibitor of mitochondrial protein synthesis, shortened the period length of the circadian rhythm in the Timex strain of Neurospora crassa by 2 hours. Both the l(+) threo and d(-) threo optical isomers had the same effect on the period of the rhythm, whereas only the d(-) threo isomer significantly inhibited mitochondrial protein synthesis. Tetracycline, another inhibitor of mitochondrial protein synthesis, did not change the period of the circadian rhythm. The effect of chloramphenicol on the circadian rhythm is, therefore, presumably not directly related to inhibition of mitochondrial protein synthesis, suggesting that chloramphenicol has other effects.
Authors:
J G Frelinger; H Motulsky; D O Woodward
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Plant physiology     Volume:  58     ISSN:  0032-0889     ISO Abbreviation:  Plant Physiol.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-06-29     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  0401224     Medline TA:  Plant Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  592-4     Citation Subset:  -    
Affiliation:
Department of Biological Sciences, Stanford University, Stanford, California 94305.
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