Document Detail

The effects of a CD81 null mutation on retinal pigment epithelium in mice.
MedLine Citation:
PMID:  20882409     Owner:  NLM     Status:  MEDLINE    
The present study examines the effects of Cd81-null mutation on the development of the retinal pigment epithelium (RPE), specifically cell size and number of cells with multiple nuclei. The outlines of RPE in retinal flat mounts were stained with rhodamine-labeled phalloidin and RPE nuclei with Hoechst stain. The RPE layer was sampled to define the number of cells, the size of the RPE cells and the number of nuclei within the cells. The Cd81-null mutation caused an increase in the number of cells within the RPE layer. The cells were smaller than those in the wild type mice. Furthermore there was an increase in the number of mono-nucleated cells. In the posterior portion of the eye there was a significant increase in the number of multi-nucleated cells. The data indicate that CD81 plays a significant role in the final stages of RPE development, controlling cell number and overall developmental pattern.
Ye Pan; David F Geisert; William E Orr; Eldon E Geisert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-09-30
Journal Detail:
Title:  Neurochemical research     Volume:  36     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-08-02     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  569-73     Citation Subset:  IM    
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MeSH Terms
Antigens, CD / genetics*
Antigens, CD81
Base Sequence
DNA Primers
Mice, Inbred BALB C
Retinal Pigment Epithelium / metabolism*
Grant Support
3P30 EY13080/EY/NEI NIH HHS; R01 EY017841/EY/NEI NIH HHS; R01 EY017841-03/EY/NEI NIH HHS; R01EY017841/EY/NEI NIH HHS
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD81; 0/Cd81 protein, mouse; 0/DNA Primers

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