| The effects of a CD81 null mutation on retinal pigment epithelium in mice. | |
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MedLine Citation:
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PMID: 20882409 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present study examines the effects of Cd81-null mutation on the development of the retinal pigment epithelium (RPE), specifically cell size and number of cells with multiple nuclei. The outlines of RPE in retinal flat mounts were stained with rhodamine-labeled phalloidin and RPE nuclei with Hoechst stain. The RPE layer was sampled to define the number of cells, the size of the RPE cells and the number of nuclei within the cells. The Cd81-null mutation caused an increase in the number of cells within the RPE layer. The cells were smaller than those in the wild type mice. Furthermore there was an increase in the number of mono-nucleated cells. In the posterior portion of the eye there was a significant increase in the number of multi-nucleated cells. The data indicate that CD81 plays a significant role in the final stages of RPE development, controlling cell number and overall developmental pattern. |
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Authors:
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Ye Pan; David F Geisert; William E Orr; Eldon E Geisert |
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Publication Detail:
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Type: Journal Article Date: 2010-09-30 |
Journal Detail:
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Title: Neurochemical research Volume: 36 ISSN: 1573-6903 ISO Abbreviation: Neurochem. Res. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 569-73 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Ave., Memphis, TN, 38163, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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