Document Detail

Effects of Caffeine on the Inflammatory Response Induced by a 15-km Run Competition.
MedLine Citation:
PMID:  23299767     Owner:  NLM     Status:  Publisher    
PURPOSE: 1) To determine the effects of caffeine supplementation on the inflammatory response (IL-6 and IL-10 levels and leukocyte numbers) induced by a 15 Km run competition and 2) to examine the effect of caffeine supplementation on the energetic metabolites as well as on the exercise induced oxidative stress. METHODS: A double-blinded study of supplementation with caffeine was performed. Athletes participating in the study (n=33) completed a 15-Km run competition. Before competition athletes took 6 mg/kg body weight of caffeine (caffeine group, n=17) or a placebo (placebo group, n=16). Blood samples were taken before and after competition (immediately and after two hours recovery). Leukocyte numbers were determined in blood. Concentrations of oxidative stress markers, antioxidants, interleukins (IL-6 and IL-10), caffeine, adrenaline and energetic metabolites were measured in plasma or serum. RESULTS: Caffeine supplementation induced higher increases in circulating total leukocytes and neutrophils, with significant differences between groups after recovery. Adrenaline, glucose and lactate levels increased after exercise, with higher increases in the caffeine group. Exercise induced significant increases in IL-6 and IL-10 plasma levels, with higher increases in the caffeine group. Caffeine supplementation induced higher increases in oxidative stress markers after the competition. CONCLUSIONS: Caffeine supplementation induced higher levels of IL-6 and IL-10 in response to exercise, enhancing the anti-inflammatory response. The caffeine-induced increase in adrenaline could be the responsible for the higher increase in IL-6 levels, as well as for the increased lactate levels. Furthermore, caffeine seems to enhance oxidative stress induced by exercise.
Pedro Tauler; Sonia Martínez; Carlos Moreno; Marta Monjo; Pau Martínez; Antoni Aguiló
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Research Group on Evidence, Lifestyles and Health, Research Institute on Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain 2Group of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain.
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