| Effects of a Caenorhabditis elegans dauer pheromone ascaroside on physiology and signal transduction pathways. | |
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MedLine Citation:
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PMID: 19190963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Daumone is one of the three purified and artificially synthesized components of the Caenorhabditis elegans dauer pheromone. It affects the major signal transduction pathways known to discriminate between developmental arrest at the dauer stage and growth to the adult [the transforming growth factor beta (TGF-beta) and daf-2/IGF1R pathways], just as natural pheromone extracts do. Transcription of daf-7/TGF-beta is reduced in pre-dauer larvae, and nuclear localization of the DAF-16/FOXO transcription factor is increased in embryos and L1 larvae exposed to synthetic daumone. However, daumone does not require the cilia in the amphidial neurons to produce these effects nor does it require the Galpha protein GPA-3 to induce dauer entry, although GPA-3 is required for dauer induction by natural dauer pheromone extracts. Synthetic daumone has physiological effects that have not been observed with natural pheromone. It is toxic at the concentrations required for bioassay and is lethal to mutants with defective cuticles. The molecular and physiological effects of daumone and natural dauer pheromone are only partially overlapping. |
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Authors:
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Marco Gallo; Donald L Riddle |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-02-04 |
Journal Detail:
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Title: Journal of chemical ecology Volume: 35 ISSN: 1573-1561 ISO Abbreviation: J. Chem. Ecol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-19 Completed Date: 2009-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505563 Medline TA: J Chem Ecol Country: United States |
Other Details:
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Languages: eng Pagination: 272-9 Citation Subset: IM |
Affiliation:
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Department of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / embryology, growth & development, metabolism* Caenorhabditis elegans Proteins / metabolism Fatty Acids / chemistry, pharmacology*, toxicity Gene Expression Regulation, Developmental Larva / growth & development Pheromones / chemistry, pharmacology*, toxicity Signal Transduction Transcription Factors / metabolism Transforming Growth Factor beta / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/Fatty Acids; 0/Pheromones; 0/Transcription Factors; 0/Transforming Growth Factor beta; 0/daf-16 protein, C elegans; 0/daumone, C elegans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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